Evidence map›Paper›PMID 32545409›Full record

ReviewCancers2020

The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020.

Flora Yan, Hannah M Knochelmann, Patrick F Morgan, John M Kaczmar, David M Neskey, Evan M Graboyes, Shaun A Nguyen, Besim Ogretmen, Anand K Sharma, Terry A Day

Abstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Immunotherapy in Head and Neck Cancer.Cancer treatment and research · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Ber-EP4 staining patterns on basal cell carcinomas.Northern clinics of Istanbul · 2023
    Article
  14. Head and neck cancer in Cali, Colombia: Population-based study.Community dentistry and oral epidemiology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Flora YanHead and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Hannah M KnochelmannDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0003-0644-123X
Patrick F MorganHead and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
John M KaczmarHead and Neck Tumor Center, Hollings Cancer Center, Department of Hematology/Oncology, Medical University of South Carolina, Charleston, SC 29425, USA.
David M NeskeyHead and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Evan M GraboyesHead and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0003-3766-468X
Shaun A NguyenHead and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
Besim OgretmenDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Anand K SharmaHead and Neck Tumor Center, Hollings Cancer Center, Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC 29425, USA.
Terry A DayHead and Neck Tumor Center, Hollings Cancer Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Funding

T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and TherapyR01DE016572 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI OGRETMEN, BESIM · 2005 to 2025
$7.4M
Improving the Timeliness and Equity of Adjuvant Therapy Following Surgery for Head and Neck CancerK08CA237858 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRABOYES, EVAN MICHAEL · 2019 to 2023
$1.3M
The tumor suppressor capability of p53 is dependent on Non-muscle Myosin IIA function in Head and Neck Cancer.K08DE026542 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NESKEY, DAVID M. · 2016 to 2018
$405k
Determining mechanisms of enhanced antitumor efficacy of four-day expanded Th17 cells for adoptive transferF30CA243307 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KNOCHELMANN, HANNAH MARIE · 2019 to 2022
$164k
Doris Duke Charitable Foundation DDCF2015209NCI NIH HHS CA243307NCI NIH HHS K08 CA237858NCI NIH HHS K08CA237858NIDCR NIH HHS DE016572NIDCR NIH HHS K08DE026542NIDCR NIH HHS T32 DE017551NIMH NIH HHS GM008716
6 · The paper itself

Abstract

Cancers that arise in the head and neck region are comprised of a heterogeneous group of malignancies that include carcinogen- and human papillomavirus (HPV)-driven mucosal squamous cell carcinoma as well as skin cancers such as cutaneous squamous cell carcinoma, basal cell carcinoma, melanoma, and Merkel cell carcinoma. These malignancies develop in critical areas for eating, talking, and breathing and are associated with substantial morbidity and mortality despite advances in treatment. Understanding of advances in the management of these various cancers is important for all multidisciplinary providers who care for patients across the cancer care continuum. Additionally, the recent Coronavirus Disease 2019 (COVID-19) pandemic has necessitated adaptations to head and neck cancer care to accommodate the mitigation of COVID-19 risk and ensure timely treatment. This review explores advances in diagnostic criteria, prognostic factors, and management for subsites including head and neck squamous cell carcinoma and the various forms of skin cancer (basal cell carcinoma, cutaneous squamous cell carcinoma, Merkel cell carcinoma, and melanoma). Then, this review summarizes emerging developments in immunotherapy, radiation therapy, cancer survivorship, and the delivery of care during the COVID-19 era.

Indexed as

COVID-19head and neck cancerhead and neck squamous cell carcinomasalivary gland cancerskin cancerthyroid cancer

Identifiers

PMID32545409
PMCPMC7352543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.