ArticleJournal of clinical medicine2020
The Relevant Hormonal Levels and Diagnostic Features of Polycystic Ovary Syndrome in Adolescents.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Diagnostic Accuracy of the Serum-free Androgen Index in Diagnosing Polycystic Ovary Syndrome: An Updated Systematic Review and Meta-analysis.Annals of African medicine · 2026Pooled it
- Evaluating the diagnostic accuracy of androgen measurement in polycystic ovary syndrome: a systematic review and diagnostic meta-analysis to inform evidence-based guidelines.Human reproduction update · 2025Pooled it
- Ultrasonographic criteria in the diagnosis of polycystic ovary syndrome: a systematic review and diagnostic meta-analysis.Human reproduction update · 2024Pooled it
- Mean platelet volume and polycystic ovary syndrome: a systematic review and meta-analysis.The Journal of international medical research · 2022Pooled it
- The Limited Diagnostic Utility of Metabolic and Inflammatory Indices in Adolescent Polycystic Ovary Syndrome: A Case-Control Study.Biomedicines · 2026Article
- Integrating evidence-based lifestyle and adjunct therapies for long-term management of polycystic ovary syndrome: mechanistic insights and clinical implications.Frontiers in reproductive health · 2026Review
- The value of anti-Mullerian hormone for diagnosing polycystic ovary syndrome in adolescents: a case-control study based on an epidemiological survey.Frontiers in reproductive health · 2026Article
- Age-stratified hormonal profiles in adolescent and young adult PCOS/PMOS: higher mid-adolescent AMH largely unexplained by BMI.Frontiers in endocrinology · 2026Article
- Follicular development impairment in polyendocrine metabolic ovarian syndrome: multidimensional pathophysiological networks and frontier therapeutic targets.Frontiers in immunology · 2026Review
- Psychiatric disorders, impulsivity and borderline personality in patients with polycystic ovary syndrome.Archives of women's mental health · 2025Article
- Brain-Specific Gata4 Downregulation in Greywick Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Mechanistic insight into nanomedicine for polycystic ovary syndrome.Molecular biology reports · 2025Review
- International evidence-based recommendations for polycystic ovary syndrome in adolescents.BMC medicine · 2025Review
- Clinical utility of FAI and SHBG in differentiating PCOS from anovulatory cycles in adolescent girls.Frontiers in pediatrics · 2025Article
- Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome:A Review.International journal of women's health · 2025Review
- Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study.Frontiers in medicine · 2024Article
- A Meta-Analysis of Observational Studies on Prolactin Levels in Women with Polycystic Ovary Syndrome.Diagnostics (Basel, Switzerland) · 2022Review
- Criteria for Diagnosis of Polycystic Ovary Syndrome during Adolescence: Literature Review.Diagnostics (Basel, Switzerland) · 2022Review
- Polycystic Ovary Syndrome in Adolescence: Challenges in Diagnosis and Management.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Article
- The Relationship between Ovarian Ultrasound Parameters and Endocrine and Metabolic Indicators in Patients with Ovarian Syndrome.Evidence-based complementary and alternative medicine : eCAM · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
relevanceThe clinical picture of polycystic ovary syndrome (PCOS) is extremely polymorphic, especially in adolescence. At the same time, the diagnostic criteria of PCOS in adolescence are still under discussion, and the hormonal parameters, including anti-Mullerian hormone range and hyperandrogenism, are not determined. The aim of the present study was to characterize the pivotal clinical and hormonal features of PCOS in adolescents and to establish the age-specific thresholds of the most essential hormonal parameters.
designA case-control study.
methodsThe study included 130 girls with PCOS according to the complete Rotterdam criteria, aged 15 to 17 years. The control group consisted of 30 healthy girls with a regular menstrual cycle of the same age. A complete clinical and laboratory examination, hormonal assays, and ultrasound of the pelvic organs were performed. The serums anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH, prolactin, estradiol, 17α-OH progesterone (17α-OHP), androstenedione, testosterone (T), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), leptin, and free androgen index (FAI) were analyzed. The diagnostic accuracy of AMH, FAI, LH/FSH, T, and androstenedione levels in predicting PCOS in adolescents was established using a logistic regression model and calculating area under the receiver operator characteristic (ROC) curve (AUC).
resultsThe serum levels of LH (9.0 (5.4-13.8) vs. 3.7 (2.5-4.7) IU/L;
conclusionsThe results of the study estimate the threshold for AMH, FAI, androstenedione, testosterone, LH/FSH, and ovarian volume, which could be suggested for use in the PCOS diagnostics in adolescents with a high sensitivity and specificity. Moreover, the combination of either four determined indexes improved the diagnostic accuracy for the PCOS detection in adolescents.
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