Evidence map›Paper›PMID 32545380›Full record

ArticleInternational journal of molecular sciences2020

Apelin Controls Angiogenesis-Dependent Glioblastoma Growth.

Anne Frisch, Stefanie Kälin, Raymond Monk, Josefine Radke, Frank L Heppner, Roland E Kälin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 41 citations in OpenAlex.

  1. miR‑222‑3p inhibits diabetic skin wound healing by targeting APLN.International journal of molecular medicine · 2026
    Article
  2. Article
  3. Linking tumour angiogenesis and tumour immunity.Nature reviews. Immunology · 2026
    Review
  4. The Apelinergic System in Kidney Disease: Novel Perspectives.International journal of molecular sciences · 2025
    Review
  5. [Apelin promotes proliferation, migration, and angiogenesis in bladder cancer by activating the FGF2/FGFR1 pathway].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  6. Review
  7. Apelin/APJ: Another Player in the Cancer Biology Network.International journal of molecular sciences · 2025
    Review
  8. Article
  9. The role of apelin in cancer.Frontiers in oncology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Angiogenic signaling pathways and anti-angiogenic therapy for cancer.Signal transduction and targeted therapy · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Anne FrischDepartment of Neuropathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.
Stefanie KälinDepartment of Neuropathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.
Raymond MonkDepartment of Neuropathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.
Josefine RadkeDepartment of Neuropathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0001-9860-2007
Frank L HeppnerDepartment of Neuropathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.
Roland E KälinDepartment of Neuropathology, Charité-Universitätsmedizin, 10117 Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DE

Funding

Anni-Hofmann Stiftung xyBerliner Krebsgesellschaft xxxFamilie Mehdorn Stiftung yyWilhelm Sander-Stiftung 2013.111.1
6 · The paper itself

Abstract

Glioblastoma (GBM) present with an abundant and aberrant tumor neo-vasculature. While rapid growth of solid tumors depends on the initiation of tumor angiogenesis, GBM also progress by infiltrative growth and vascular co-option. The angiogenic factor apelin (

Indexed as

AnimalsApelinBrain NeoplasmsCell Line, TumorGene Expression Regulation, NeoplasticGlioblastomaHumansIntercellular Signaling Peptides and ProteinsMagnetic Resonance ImagingMice, KnockoutNeoplasms, ExperimentalNeovascularization, PathologicTumor MicroenvironmentXenograft Model Antitumor AssaysApelinapelin-13 peptideAPLN protein, humanApln protein, mouseIntercellular Signaling Peptides and ProteinsApelin-13APLNAPLNRGBM angiogenesisglioblastoma

Identifiers

PMID32545380
PMCPMC7312290
OpenAlexW3035527255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.