Evidence map›Paper›PMID 32545310›Full record

ArticleInternational journal of molecular sciences2020

Serum Biomarkers of Cardiovascular Remodelling Reflect Extra-Valvular Cardiac Damage in Patients with Severe Aortic Stenosis.

Laura Bäz, Gudrun Dannberg, Katja Grün, Julian Westphal, Sven Möbius-Winkler, Christian Jung, Alexander Pfeil, P Christian Schulze, Marcus Franz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. The Staging of Cardiac Damage for Aortic Stenosis: A Review.Structural heart : the journal of the Heart Team · 2025
    Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura BäzDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.
Gudrun DannbergDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.
Katja GrünDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.
Julian WestphalDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.ORCID 0000-0002-7488-4000
Sven Möbius-WinklerDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.ORCID 0000-0003-1319-6738
Christian JungDivision of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.
Alexander PfeilDepartment of Internal Medicine III, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.
P Christian SchulzeDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.
Marcus FranzDepartment of Internal Medicine I, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany.ORCID 0000-0001-6543-4684
Friedrich Schiller University Jena · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with aortic stenosis (AS), a novel staging classification of extra-valvular left and right heart damage with prognostic relevance was introduced in 2017. The aim of the study was to evaluate the biomarkers of cardiovascular tissue remodelling in relation to this novel staging classification. Patients were categorized according to the novel staging classification into stages 0 to 4. The levels of matrix metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinases 1 (TIMP-1), B and C domain containing tenascin-C (B

Indexed as

Vascular RemodelingAgedAged, 80 and overAortic Valve StenosisBiomarkersCase-Control StudiesEndothelin-1FemaleHumansLipocalin-2MaleMatrix Metalloproteinase 9Prospective StudiesTenascinTissue Inhibitor of Metalloproteinase-1Transcatheter Aortic Valve ReplacementBiomarkersEndothelin-1LCN2 protein, humanLipocalin-2Matrix Metalloproteinase 9MMP9 protein, humanTenascinTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1TNC protein, humanaortic stenosisbiomarkercardiovascular remodellingextra-valvular cardiac damagerisk stratificationstaging

Identifiers

PMID32545310
PMCPMC7312014
OpenAlexW3034565633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.