Evidence map›Paper›PMID 32545293›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis and Studies of the Inhibitory Effect of Hydroxylated Phenylpropanoids and Biphenols Derivatives on Tyrosinase and Laccase Enzymes.

Maria Antonietta Dettori, Davide Fabbri, Alessandro Dessì, Roberto Dallocchio, Paola Carta, Claudia Honisch, Paolo Ruzza, Donatella Farina, Rossana Migheli, Pier Andrea Serra and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antamanide Analogs as Potential Inhibitors of Tyrosinase.International journal of molecular sciences · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Maria Antonietta DettoriIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.
Davide FabbriIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0002-3947-5164
Alessandro DessìIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0001-8258-7332
Roberto DallocchioIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.
Paola CartaIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0001-8749-6093
Claudia HonischDipartimento di Scienze Chimiche, Università degli Studi di Padova, 35131 Padova, Italy.ORCID 0000-0001-9720-6176
Paolo RuzzaDipartimento di Scienze Chimiche, Università degli Studi di Padova, 35131 Padova, Italy.ORCID 0000-0002-5596-9295
Donatella FarinaDipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Università degli Studi, 07100 Sassari, Italy.
Rossana MigheliDipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Università degli Studi, 07100 Sassari, Italy.
Pier Andrea SerraDipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Università degli Studi, 07100 Sassari, Italy.
Roberto A PantaleoniIstituto di Ricerca sugli Ecosistemi Terrestri, Consiglio Nazionale Ricerca, 07100 Sassari, Italy.ORCID 0000-0003-0118-7244
Xenia FoisIstituto di Ricerca sugli Ecosistemi Terrestri, Consiglio Nazionale Ricerca, 07100 Sassari, Italy.
Gaia RocchittaDipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Università degli Studi, 07100 Sassari, Italy.ORCID 0000-0002-4319-4197
Giovanna DeloguIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.
Istituto di Chimica Biomolecolare · ITUniversity of Sassari · ITUniversity of Padua · ITResearch Institute on Sustainable Economic Growth · IT

Funding

Regione Autonoma della Sardegna L.R. 7, 2007, CRP 25114Università degli Studi di Sassari Fondo di Ateneo per la ricerca 2019
6 · The paper itself

Abstract

The impaired activity of tyrosinase and laccase can provoke serious concerns in the life cycles of mammals, insects and microorganisms. Investigation of inhibitors of these two enzymes may lead to the discovery of whitening agents, medicinal products, anti-browning substances and compounds for controlling harmful insects and bacteria. A small collection of novel reversible tyrosinase and laccase inhibitors with a phenylpropanoid and hydroxylated biphenyl core was prepared using naturally occurring compounds and their activity was measured by spectrophotometric and electrochemical assays. Biosensors based on tyrosinase and laccase enzymes were constructed and used to detect the type of protein-ligand interaction and half maximal inhibitory concentration (IC

Indexed as

AnimalsCatalytic DomainCell SurvivalCrystallography, X-RayEnzyme InhibitorsHydroxylationLaccaseModels, MolecularMonophenol MonooxygenasePC12 CellsPhenolPropanolsProtein ConformationRatsTenebrioEnzyme InhibitorsLaccaseMonophenol MonooxygenasePhenolPropanolsbiosensorschitin inhibitorsoxidase and polyphenol oxidasepolyphenolsSAR studiesspectrophotometric assaytyrosinase inhibitorsviability

Identifiers

PMID32545293
PMCPMC7321210
OpenAlexW3034458486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.