Evidence map›Paper›PMID 32545290›Full record

ArticleMolecules (Basel, Switzerland)2020

One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents.

Samra Farooq, Aqsa Mazhar, Areej Ghouri, Ihsan-Ul-Haq, Naseem Ullah

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Phytochemical analysis and comprehensive evaluation of pharmacological potential ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
  3. BioMed research international · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samra FarooqDepartment of Pharmacy, Faculty of Biological Science, Quaid-I-Azam University, Islamabad 45320, Pakistan.ORCID 0000-0001-8794-6357
Aqsa MazharDepartment of Pharmacy, Faculty of Biological Science, Quaid-I-Azam University, Islamabad 45320, Pakistan.ORCID 0000-0003-3331-1377
Areej GhouriDepartment of Pharmacy, Faculty of Biological Science, Quaid-I-Azam University, Islamabad 45320, Pakistan.
Ihsan-Ul-HaqDepartment of Pharmacy, Faculty of Biological Science, Quaid-I-Azam University, Islamabad 45320, Pakistan.ORCID 0000-0001-6413-5957
Naseem UllahDepartment of Pharmacy, Faculty of Biological Science, Quaid-I-Azam University, Islamabad 45320, Pakistan.ORCID 0000-0001-8172-506X

Funding

Higher Education Commission, Pakistan PIN NO. 315-11229-2MD3-036
6 · The paper itself

Abstract

Mankind has always suffered from multiple diseases. Therefore, there has been a rigorous need in the field of medicinal chemistry for the design and discovery of new and potent molecular entities. In this work, thirteen tetrahydroquinoline derivatives were synthesized and evaluated biologically for their antioxidant, α-amylase enzyme inhibitory, anti-proliferative and anti-inflammatory activities.

Indexed as

Administration, Oralalpha-AmylasesAnimalsAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsAspirinCarrageenanCell Line, TumorCell SurvivalCisplatinDisease Models, AnimalEdemaEnzyme InhibitorsHumansMale1,2,3,4-tetrahydroquinolinealpha-AmylasesAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsAspirinCarrageenanCisplatinEnzyme InhibitorsMannich BasesQuinolinesantioxidantin vivo anti-inflammatory activityMTT assaytetrahydroquinolineα-amylase enzyme inhibition

Identifiers

PMID32545290
PMCPMC7321408

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.