Evidence map›Paper›PMID 32545254›Full record

ArticleBiomolecules2020

Development of 6'-

Yeon Hee Ban, Myoung Chong Song, Hee Jin Kim, Heejeong Lee, Jae Bok Wi, Je Won Park, Dong Gun Lee, Yeo Joon Yoon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Facile and selectiveGreen chemistry : an international journal and green chemistry resource : GC · 2022
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yeon Hee BanNatural Products Research Institute, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 08826, Korea.ORCID 0000-0002-6343-8603
Myoung Chong SongNatural Products Research Institute, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 08826, Korea.ORCID 0000-0002-3658-025X
Hee Jin KimDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea.
Heejeong LeeSchool of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daehakro 80, Bukgu, Daegu 41566, Korea.
Jae Bok WiDepartment of Integrated Biomedical and Life Sciences, Korea University, Seoul 02841, Korea.
Je Won ParkDepartment of Integrated Biomedical and Life Sciences, Korea University, Seoul 02841, Korea.
Dong Gun LeeSchool of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daehakro 80, Bukgu, Daegu 41566, Korea.
Yeo Joon YoonNatural Products Research Institute, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 08826, Korea.ORCID 0000-0002-3637-3103
Seoul National University · KRKorea University · KRKyungpook National University · KREwha Womans University · KR

Funding

Cooperative Research Program for Agriculture Science and Technology Development PJ01316001National Research Foundation of Korea (NRF) Grants funded by the Ministry of Education 2019R1I1A1A01062130National Research Foundation of Korea (NRF) Grants funded by the Ministry of Science and ICT 2019R1A2B5B03069338National Research Foundation of Korea (NRF) Grants funded by the Ministry of Science and ICT 2020R1A2B5B01001905National Research Foundation of Korea (NRF) Grants funded by the Ministry of Science and ICT 2020R1A2C2008061
6 · The paper itself

Abstract

The development of new aminoglycoside (AG) antibiotics has been required to overcome the resistance mechanism of AG-modifying enzymes (AMEs) of AG-resistant pathogens. The AG acetyltransferase, AAC(6')-APH(2″), one of the most typical AMEs, exhibiting substrate promiscuity towards a variety of AGs and acyl-CoAs, was employed to enzymatically synthesize new 6'-

Indexed as

AcylationAnti-Bacterial AgentsCells, CulturedDrug Resistance, BacterialEscherichia coliGentamicinsGram-Negative BacteriaHEK293 CellsHumansMicrobial Sensitivity TestsPhosphotransferases (Alcohol Group Acceptor)Pseudomonas aeruginosaStaphylococcus aureusToxicity Testsaminoglycoside 2''-phosphotransferaseAnti-Bacterial AgentsGentamicinsisepamicinPhosphotransferases (Alcohol Group Acceptor)6′-N-acylationantibacterial activitycytotoxicityenzymatic synthesisisepamicin analogs

Identifiers

PMID32545254
PMCPMC7356214
OpenAlexW3034785302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.