Evidence map›Paper›PMID 32545151›Full record

ReviewNutrients2020

Fetal-Maternal Exposure to Endocrine Disruptors: Correlation with Diet Intake and Pregnancy Outcomes.

Alessandro Rolfo, Anna Maria Nuzzo, Ramona De Amicis, Laura Moretti, Simona Bertoli, Alessandro Leone

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 189 citations in OpenAlex.

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  4. Occupational Risk Factors and Hypertensive Disorders in Pregnancy: A Systematic Review.International journal of environmental research and public health · 2021
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alessandro RolfoDepartment of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy.ORCID 0000-0001-6730-8067
Anna Maria NuzzoDepartment of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy.ORCID 0000-0001-9115-2007
Ramona De AmicisInternational Center for the Assessment of Nutritional Status (ICANS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Sandro Botticelli 21, 20133 Milan, Italy.ORCID 0000-0003-0403-5465
Laura MorettiDepartment of Surgical Sciences, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy.
Simona BertoliInternational Center for the Assessment of Nutritional Status (ICANS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Sandro Botticelli 21, 20133 Milan, Italy.ORCID 0000-0001-5867-8074
Alessandro LeoneInternational Center for the Assessment of Nutritional Status (ICANS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Sandro Botticelli 21, 20133 Milan, Italy.ORCID 0000-0001-8063-8490
University of Milan · ITUniversity of Turin · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca 2015SHM58M
6 · The paper itself

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evidence obtained on in vitro and animal models as well as by epidemiologic and population studies strongly indicated that endocrine disruptors could negatively impact fetal and placental health by interfering with the embryonic developing epigenome, thus establishing disease paths into adulthood. Moreover, EDCs could cause and/or contribute to the onset of severe gestational conditions as Preeclampsia (PE), Fetal Growth Restriction (FGR) and gestational diabetes in pregnancy, as well as obesity, diabetes and cardiovascular complications in reproductive age. Therefore, despite contrasting data being present in the literature, endocrine disruptors must be considered as a therapeutic target. Future actions aimed at reducing or eliminating EDC exposure during the perinatal period are mandatory to guarantee pregnancy success and preserve fetal and adult health.

Indexed as

AdultAnimalsBenzhydryl CompoundsBisphenol A CompoundsCardiovascular DiseasesDiabetes, GestationalEndocrine DisruptorsFemaleFetal DevelopmentFetal Growth RetardationHumansMaternal ExposureMaternal-Fetal ExchangePhenolsPhthalic AcidsPlacentaBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsPhenolsphthalic acidPhthalic Acidsbisphenol Adietendocrine-disrupting chemicals (EDCs)phthalatsplacentapregnancypregnancy pathologies

Identifiers

PMID32545151
PMCPMC7353272
OpenAlexW3034677636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.