Evidence map›Paper›PMID 32544855›Full record

ArticleNeuroImage. Clinical2020

Baseline cerebral metabolism predicts fatigue and cognition in Multiple Sclerosis patients.

Kl West, Dk Sivakolundu, Gb Maruthy, Md Zuppichini, P Liu, Bp Thomas, Js Spence, H Lu, Dt Okuda, B Rypma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Kl WestSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA. Electronic address: kathryn.west@utdallas.edu.
Dk SivakolunduSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA.
Gb MaruthySchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA.
Md ZuppichiniSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA.
P LiuDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Bp ThomasAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Js SpenceSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA.
H LuDepartment of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Dt OkudaDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
B RypmaSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, USA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The University of Texas at Dallas · USThe University of Texas Southwestern Medical Center · USJohns Hopkins University · US

Funding

BOLD and its discontents: age-differences in the neurophysiology of fMRI signalR01AG047972 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, RYPMA, BART · 2015 to 2019
$1.7M
NIA NIH HHS R01 AG047972
6 · The paper itself

Abstract

backgroundCerebral metabolic rate of oxygen (CMRO

objectiveWe sought to utilize T

methodsWe measured venous oxygenation (TRUST) and cerebral blood flow (PC-MRI) in superior sagittal sinus to calculate global CMRO

resultsWe observed lower CMRO

conclusionAltogether, these results suggest that increased CMRO

Indexed as

AdultAtrophyCerebrovascular CirculationCognitionCognitive DysfunctionFatigueFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisWhite MatterCerebral blood flowCognitionEnergy metabolismFatigueMRIMultiple Sclerosis

Identifiers

PMID32544855
PMCPMC7298673
OpenAlexW3033579374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.