ArticleJournal of psychiatric research2020
Parsing differences in amygdala volume among individuals with and without social and generalized anxiety disorders across the lifespan.
Article in Journal of psychiatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Multimodal phenotypic classification of generalized anxiety and panic using structural MRI data and psychosocial factors: machine learning results from the German National Cohort (NAKO) study.Translational psychiatry · 2026Article
- Nuclei-Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug-Resistant Focal Epilepsy.Annals of clinical and translational neurology · 2025Article
- Regulator of G protein signalling 14 (RGS14) protein expression profile in the adult mouse brain.The European journal of neuroscience · 2024Article
- Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Anxiety in children and youth with autism spectrum disorder and the association with amygdala subnuclei structure.Autism : the international journal of research and practice · 2023Article
- Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.Translational psychiatry · 2023Article
- RGS14 expression in CA2 hippocampus, amygdala, and basal ganglia: Implications for human brain physiology and disease.Hippocampus · 2023Review
- Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.Molecular psychiatry · 2023Article
- Gray-Matter Morphometry of Internalizing-Symptom Dimensions During Adolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2022Article
- Is there hemispheric specialization in the chronic pain brain?Experimental neurology · 2022Review
- Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.Biological psychiatry · 2022Article
- Amygdala-driven apnea and the chemoreceptive origin of anxiety.Biological psychology · 2022Review
- Amygdala Allostasis and Early Life Adversity: Considering Excitotoxicity and Inescapability in the Sequelae of Stress.Frontiers in human neuroscience · 2021Article
- Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults.General psychiatry · 2021Review
- Voluntary exercise prevents and eradicates anxiety-like behavior by influencing parvalbumin-positive neurons, perineuronal nets, and microglia activation in corticolimbic regions of neuropathic pain rats.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Structural differences in the amygdala (AMG) are implicated in anxiety and observed among individuals with generalized (GAD) and social anxiety (SAD) disorders. Findings have been mixed, perhaps because studies rarely examine differences between GAD and SAD, test comorbidity, or examine age-related differences. We tested AMG volume differences among a sample of adults and youth with/without SAD and GAD. Participants (N = 242; ages 7-60 years) completed an MRI scan, diagnostic interviews, and anxiety symptom measures. Groups were formed from diagnostic interviews: 1) Typically developing (TD; n = 91); 2) GAD (n = 53); 3) SAD (n = 35); and 4) comorbid SAD/GAD (n = 63). We used analysis of covariance with a bonferroni correction to examine group differences in AMG volume. The SAD and comorbid SAD/GAD groups exhibited increased bilateral AMG volume compared to the TD group. GAD and TD groups did not differ from each other in AMG size. The SAD, but not the comorbid SAD/GAD group, displayed greater right AMG size relative to the GAD group. SAD and comorbid SAD/GAD groups did not differ from the GAD group in left AMG volume. SAD and SAD/GAD groups did not exhibit different bilateral AMG size. Linear regression analyses demonstrated that greater social anxiety but not generalized anxiety symptom severity was associated with enlarged AMG volume. Age was not associated with AMG volume and nor did age moderate any group or symptom effects. Future longitudinal studies should examine whether larger AMG volume is a unique biomarker for SAD across the lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.