Evidence map›Paper›PMID 32544376›Full record

ArticleHuman vaccines & immunotherapeutics2020

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity.

Katherine Schultheis, Holly M Pugh, Janet Oh, Jacklyn Nguyen, Bryan Yung, Charles Reed, Neil Cooch, Jing Chen, Jian Yan, Kar Muthumani and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Katherine SchultheisInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Holly M PughInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Janet OhInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Jacklyn NguyenInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Bryan YungInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Charles ReedInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Neil CoochInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Jing ChenInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Jian YanInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Kar MuthumaniVaccine & Immunotherapy Center, The Wistar Institute , Philadelphia, PA, USA.
Laurent M HumeauInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
David B WeinerVaccine & Immunotherapy Center, The Wistar Institute , Philadelphia, PA, USA.
Kate E BroderickInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Trevor R F SmithInovio Pharmaceuticals , Plymouth Meeting, PA, USA.
Inovio Pharmaceuticals (United States) · USThe Wistar Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory Syncytial virus (RSV) is a major threat to many vulnerable populations. There are currently no approved vaccines, and RSV remains a high unmet global medical need. Here we describe the employment of a novel synthetic DNA-encoded antibody technology platform to develop and deliver an engineered human DNA-encoded monoclonal antibody (dMAb

Indexed as

Respiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralSigmodontinaeTissue DistributionViral Fusion ProteinsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralRespiratory Syncytial Virus VaccinesViral Fusion Proteinsactive immunophrophylaxiscotton ratDNA-encoded antibodyelectroporationplasmid DNARespiratory syncytial virussingle-chain antibody

Identifiers

PMID32544376
PMCPMC7553682
OpenAlexW3034523742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.