ArticleThe New phytologist2020
A new mode of NPR1 action via an NB-ARC-NPR1 fusion protein negatively regulates the defence response in wheat to stem rust pathogen.
Article in The New phytologist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 35 citations in OpenAlex.
- Functional Dissection of a Wheat NLR Protein Reveals a Minimal Active Region and Key Regulatory Sites for Immune Signalling.Molecular plant pathology · 2026Article
- Benchmarking methods for genome annotation using nanopore direct RNA in a non-model crop plant.Bioinformatics advances · 2026Article
- Discovering leaf and stripe rust resistance in soft red winter wheat through genome-wide association studies.The plant genome · 2025Article
- Genetic dissection of Septoria tritici blotch and Septoria nodorum blotch resistance in wheat using GWAS.Frontiers in plant science · 2025Article
- Review
- Enhancement of broad-spectrum disease resistance in wheat through key genes involved in systemic acquired resistance.Frontiers in plant science · 2024Review
- Genome-wide identification of the CYP82 gene family in cucumber and functional characterization ofPeerJ · 2024Article
- The Underexplored Mechanisms of Wheat Resistance to Leaf Rust.Plants (Basel, Switzerland) · 2023Review
- Transcriptomic analysis of wheat reveals possible resistance mechanism mediated by Yr10 to stripe rust.Stress biology · 2023Article
- Selection of reference genes for RT-qPCR analysis of rice with Rhizoctonia solani infection and biocontrol PGPR/KSi application.Molecular biology reports · 2023Article
- Molecular Mechanisms of the Co-Evolution of Wheat and Rust Pathogens.Plants (Basel, Switzerland) · 2023Review
- A necessary considering factor for breeding: growth-defense tradeoff in plants.Stress biology · 2023Review
- Physiological response ofFrontiers in plant science · 2023Article
- Show me your ID: NLR immune receptors with integrated domains in plants.Essays in biochemistry · 2022Article
- Discovery of Resistance Genes in Rye by Targeted Long-Read Sequencing and Association Genetics.Cells · 2022Article
- Article
- TaPR1 Interacts With TaTLP1Frontiers in plant science · 2022Article
- Two alternative splicing variants of a wheat geneFrontiers in plant science · 2022Article
- Harnessing genetic resistance to rusts in wheat and integrated rust management methods to develop more durable resistant cultivars.Frontiers in plant science · 2022Review
- RNAi-mediated stable silencing of TaCSN5 confers broad-spectrum resistance to Puccinia striiformis f. sp. tritici.Molecular plant pathology · 2021Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NPR1 has been found to be a key transcriptional regulator in some plant defence responses. There are nine NPR1 homologues (TaNPR1) in wheat, but little research has been done to understand the function of those NPR1-like genes in the wheat defence response against stem rust (Puccinia graminis f. sp. tritici) pathogens. We used bioinformatics and reverse genetics approaches to study the expression and function of each TaNPR1. We found six members of TaNPR1 located on homoeologous group 3 chromosomes (designated as TaG3NPR1) and three on homoeologous group 7 chromosomes (designated as TaG7NPR1). The group 3 NPR1 proteins regulate transcription of SA-responsive PR genes. Downregulation of all the TaNPR1 homologues via virus-induced gene co-silencing resulted in enhanced resistance to stem rust. More specifically downregulating TaG7NPR1 homeologues or Ta7ANPR1 expression resulted in stem rust resistance phenotype. By contrast, knocking down TaG3NPR1 alone did not show visible phenotypic changes in response to the rust pathogen. Knocking out Ta7ANPR1 enhanced resistance to stem rust. The Ta7ANPR1 locus is alternatively spliced under pathogen inoculated conditions. We discovered a new mode of NPR1 action in wheat at the Ta7ANPR1 locus through an NB-ARC-NPR1 fusion protein negatively regulating the defence to stem rust infection.
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