Evidence map›Paper›PMID 32543946›Full record

ArticleThe British journal of radiology2020

Comparison of radiographer interobserver image registration variability using cone beam CT and MR for cervix radiotherapy.

John Rodgers, Rosie Hales, Lee Whiteside, Jacqui Parker, Louise McHugh, Anthea Cree, Marcel van Herk, Ananya Choudhury, Peter Hoskin, Alan McWilliam and 1 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

John RodgersDepartment of Radiotherapy, The Christie NHS Foundation Trust, Manchester, UK.
Rosie HalesDepartment of Radiotherapy, The Christie NHS Foundation Trust, Manchester, UK.
Lee WhitesideDepartment of Radiotherapy, The Christie NHS Foundation Trust, Manchester, UK.
Jacqui ParkerDepartment of Radiotherapy, The Christie NHS Foundation Trust, Manchester, UK.
Louise McHughDepartment of Radiotherapy, The Christie NHS Foundation Trust, Manchester, UK.
Anthea CreeDepartment of Clinical Oncology, The Christie Hospital NHS Foundation Trust, Manchester, UK.
Marcel van HerkDepartment of Clinical Oncology, The Christie Hospital NHS Foundation Trust, Manchester, UK.
Ananya ChoudhuryDepartment of Clinical Oncology, The Christie Hospital NHS Foundation Trust, Manchester, UK.
Peter HoskinDepartment of Clinical Oncology, The Christie Hospital NHS Foundation Trust, Manchester, UK.
Alan McWilliamDepartment of Clinical Oncology, The Christie Hospital NHS Foundation Trust, Manchester, UK.
Cynthia L EcclesDepartment of Radiotherapy, The Christie NHS Foundation Trust, Manchester, UK.ORCID http://orcid.org/0000-0002-5445-5428
Manchester Academic Health Science Centre · GBThe Christie NHS Foundation Trust · GB

Funding

Cancer Research UK 21993
6 · The paper itself

Abstract

objectivesThe aim of this study was to assess the consistency of therapy radiographers performing image registration using cone beam computed tomography (CBCT)-CT, magnetic resonance (MR)-CT, and MR-MR image guidance for cervix cancer radiotherapy and to assess that MR-based image guidance is not inferior to CBCT standard practice.

methods10 patients receiving cervix radiation therapy underwent daily CBCT guidance and magnetic resonance (MR) imaging weekly during treatment. Offline registration of each MR image, and corresponding CBCT, to planning CT was performed by five radiographers. MR images were also registered to the earliest MR interobserver variation was assessed using modified Bland-Altman analysis with clinically acceptable 95% limits of agreement (LoA) defined as ±5.0 mm.

results30 CBCT-CT, 30 MR-CT and 20 MR-MR registrations were performed by each observer. Registration variations between CBCT-CT and MR-CT were minor and both strategies resulted in 95% LoA over the clinical threshold in the anteroposterior direction (CBCT-CT ±5.8 mm, MR-CT ±5.4 mm). MR-MR registrations achieved a significantly improved 95% LoA in the anteroposterior direction (±4.3 mm). All strategies demonstrated similar results in lateral and longitudinal directions.

conclusionThe magnitude of interobserver variations between CBCT-CT and MR-CT were similar, confirming that MR-CT radiotherapy workflows are comparable to CBCT-CT image-guided radiotherapy. Our results suggest MR-MR radiotherapy workflows may be a superior registration strategy. ADVANCES IN KNOWLEDGE: This is the first publication quantifying interobserver registration of multimodality image registration strategies for cervix radical radiotherapy patients.

Indexed as

Observer VariationAdultAgedCervix UteriCone-Beam Computed TomographyFemaleHumansMagnetic Resonance ImagingMiddle AgedMultimodal ImagingRadiotherapy, Image-GuidedUterine Cervical Neoplasms

Identifiers

PMID32543946
PMCPMC7446016
OpenAlexW3035246217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.