Evidence map›Paper›PMID 32543909›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Impact of Regulatory T Cells on Type 2 Alveolar Epithelial Cell Transcriptomes during Resolution of Acute Lung Injury and Contributions of IFN-γ.

Jason R Mock, Catherine F Dial, Miriya K Tune, Rodney C Gilmore, Wanda K O'Neal, Hong Dang, Claire M Doerschuk

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Evaluating the role of alveolar macrophages in tolerance to ozone.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  7. Review
  8. T Regulatory Mechanisms in Airway and Interstitial Lung Disease.Seminars in respiratory and critical care medicine · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. RNA Sequencing Analysis of CD4Critical care explorations · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jason R MockDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine.ORCID 0000-0002-7022-0629
Catherine F DialDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine.
Miriya K TuneDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine.
Rodney C GilmoreMarsico Lung Institute, and.
Wanda K O'NealDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine.
Hong DangMarsico Lung Institute, and.
Claire M DoerschukDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine.ORCID 0000-0003-2638-3321

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
Rho-mediated Signaling in Lung Endothelial Cells Induced by Neutrophil AdhesionR01HL114388 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURRIDGE, KEITH, DOERSCHUK, CLAIRE M · 2012 to 2016
$3.0M
Trafficking and function of macrophage subpopulations within the lung microenvironment during pneumoniaR01HL145396 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOERSCHUK, CLAIRE M · 2019 to 2022
$2.3M
Application of Omics in Lung DiseaseK12HL119998 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DOERSCHUK, CLAIRE M · 2013 to 2017
$1.4M
Regulatory T Cells Promote Alveolar Epithelial RepairK08HL129075 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOCK, JASON ROBERT · 2016 to 2019
$685k
Defining the Role of Regulatory T Cell-Derived MMP12 in Acute Lung Injury ResolutionR03HL145255 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MOCK, JASON ROBERT · 2018 to 2019
$156k
NCI NIH HHS P30 CA016086NHLBI NIH HHS K08 HL129075NHLBI NIH HHS K12 HL119998NHLBI NIH HHS R01 HL114388NHLBI NIH HHS R01 HL145396NHLBI NIH HHS R03 HL145255NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

By enhancing tissue repair and modulating immune responses, Foxp3

Indexed as

Acute Lung InjuryAlveolar Epithelial CellsAnimalsB-LymphocytesFemaleForkhead Transcription FactorsInflammationInterferon-gammaLungMacrophagesMaleMiceMice, Inbred C57BLSignal TransductionT-Lymphocytes, RegulatoryTranscriptomeForkhead Transcription FactorsInterferon-gammaacute lung injuryFoxp3IFN-γregulatory T cellstype 2 alveolar epithelial cells

Identifiers

PMID32543909
PMCPMC7528916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.