ArticleBiomacromolecules2020
Bio-Based Lignin Nanocarriers Loaded with Fungicides as a Versatile Platform for Drug Delivery in Plants.
Article in Biomacromolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 144 citations in OpenAlex.
- Impact of Type of Lignin, Alkaline and Lignosulfonate, on Release and Soil Adsorption of Methoxyfenozide Delivered with Lignin-ACS omega · 2026Article
- Nanoparticle Applications in Plant Biotechnology: A Comprehensive Review.Plants (Basel, Switzerland) · 2026Review
- Nanotechnology-driven strategies to overcome azole resistance inFrontiers in plant science · 2026Review
- Engineering of Industrial Kraft Lignin: The Role of Esterification Methods in Lignin Nanoparticle Self-Assembly.Biomacromolecules · 2025Article
- Hydrophobic Coating of Paperboard Using Oak Wood-Derived Lignin Nanoparticles and Chitosan Composites.Molecules (Basel, Switzerland) · 2025Article
- Lignin-based nanoencapsulation for sustainable herbicide delivery: controlled release and bioactivity of 2,4-D and MCPA compared to commercial formulations.Scientific reports · 2025Article
- Lignin Nanoparticles as pH-responsive Nanocarriers for Gastric-Irritant Oral Drug Aspirin.Current drug delivery · 2025Article
- Advancements in the nanodelivery of azole-based fungicides to control oil palm pathogenic fungi.Heliyon · 2024Review
- Fungicide-Loaded Liposomes for the Treatment of Fungal Diseases in Agriculture: An Assessment ofInternational journal of molecular sciences · 2024Article
- Modulation of Methoxyfenozide Release from Lignin Nanoparticles Made of Lignin Grafted with PCL by ROP and Acylation Grafting Methods.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- A Study on the Use of the Phyto-Courier Technology in Tobacco Leaves Infected byInternational journal of molecular sciences · 2023Article
- Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials.Polymers · 2023Review
- Lignin, the Lignification Process, and Advanced, Lignin-Based Materials.International journal of molecular sciences · 2023Review
- High value valorization of lignin as environmental benign antimicrobial.Materials today. Bio · 2023Review
- Multifunctional Nanocarriers Based on Chitosan Oligomers and Graphitic Carbon Nitride Assembly.Materials (Basel, Switzerland) · 2022Article
- 1-Tetradecanol, Diethyl Phthalate and Tween 80 Assist in the Formation of Thermo-Responsive Azoxystrobin Nanoparticles.Molecules (Basel, Switzerland) · 2022Article
- Advances in Biopolymeric Nanopesticides: A New Eco-Friendly/Eco-Protective Perspective in Precision Agriculture.Nanomaterials (Basel, Switzerland) · 2022Review
- Toxicity Assessment and Control of Early Blight and Stem Rot ofJournal of xenobiotics · 2022Article
- Lignin-based nano-enabled agriculture: A mini-review.Frontiers in plant science · 2022Review
- Multifunctional lignin-based nanocomposites and nanohybrids.Green chemistry : an international journal and green chemistry resource : GC · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin-based nano- and microcarriers are a promising biodegradable drug delivery platform inside of plants. Many wood-decaying fungi are capable of degrading the wood component lignin by segregated lignases. These fungi are responsible for severe financial damage in agriculture, and many of these plant diseases cannot be treated today. However, enzymatic degradation is also an attractive handle to achieve a controlled release of drugs from artificial lignin vehicles. Herein, chemically cross-linked lignin nanocarriers (NCs) were prepared by aza-Michael addition in miniemulsion, followed by solvent evaporation. The cross-linking of lignin was achieved with the bio-based amines (spermine and spermidine). Several fungicides-namely, azoxystrobin, pyraclostrobin, tebuconazole, and boscalid-were encapsulated in situ during the miniemulsion polymerization, demonstrating the versatility of the method. Lignin NCs with diameters of 200-300 nm (determined by dynamic light scattering) were obtained, with high encapsulation efficiencies (70-99%, depending on the drug solubility). Lignin NCs successfully inhibited the growth of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.