ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer's disease.Translational psychiatry · 2024Pooled it
- Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases.Neural regeneration research · 2026Article
- Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms.Molecular neurodegeneration · 2026Article
- A blood based mitochondrial functional index biomarker for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mitochondrial haplogroups, but not heteroplasmy, are associated with midlife cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Review
- mtDNA "nomenclutter" and its consequences on the interpretation of genetic data.BMC ecology and evolution · 2024Article
- Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids.Stem cell research & therapy · 2023Article
- The role of mitochondrial genome abundance in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Mitochondrial haplogroups and cognitive progression in Parkinson's disease.Brain : a journal of neurology · 2023Article
- Mitochondrial DNA abnormalities and metabolic syndrome.Frontiers in cell and developmental biology · 2023Review
- Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer's disease.Journal of neuroinflammation · 2022Review
- Mitochondrial function and Aβ in Alzheimer's disease postmortem brain.Neurobiology of disease · 2022Article
- Article
- Mitochondrial Genetics Reinforces Multiple Layers of Interaction in Alzheimer's Disease.Biomedicines · 2022Article
- Article
- Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change.Journal of Alzheimer's disease : JAD · 2022Article
- The heterogeneity among subgroups of haplogroup J influencing Alzheimer's disease risk.Journal of advanced research · 2021Article
- Mitochondrial links between brain aging and Alzheimer's disease.Translational neurodegeneration · 2021Review
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Authors and funding
14 authors.
Funding
Abstract
introductionInherited mitochondrial DNA (mtDNA) variants may influence Alzheimer's disease (AD) risk.
methodsWe sequenced mtDNA from 146 AD and 265 cognitively normal (CN) subjects from the University of Kansas AD Center (KUADC) and assigned haplogroups. We further considered 244 AD and 242 CN AD Neuroimaging Initiative (ADNI) subjects with equivalent data.
resultsWithout applying multiple comparisons corrections, KUADC haplogroup J AD and CN frequencies were 16.4% versus 7.6% (P = .007), and haplogroup K AD and CN frequencies were 4.8% versus 10.2% (P = .063). ADNI haplogroup J AD and CN frequencies were 10.7% versus 7.0% (P = .20), and haplogroup K frequencies were 4.9% versus 8.7% (P = .11). For the combined 390 AD and 507 CN cases haplogroup J frequencies were 12.8% versus 7.3% (P = .006), odds ratio (OR) = 1.87, and haplogroup K frequencies were 4.9% versus 9.5% (P = .010), OR = 0.49. Associations remained significant after adjusting for apolipoprotein E, age, and sex.
conclusionThis exploratory analysis suggests inherited mtDNA variants influence AD risk.
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