ArticleAngewandte Chemie (International ed. in English)2020
Reactions in Tirapazamine Induced by the Attachment of Low-Energy Electrons: Dissociation Versus Roaming of OH.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Article
- Copper-coordinated engineered nanoreactors with self-amplifying OJournal of nanobiotechnology · 2025Article
- Article
- Supramolecular Aggregation-Induced Emission Photosensitizer Encapsulated by Cucurbit[8]uril Nanocavity Boosts Hypoxia-Activated Tumor Therapy.ACS applied nano materials · 2025Article
- Hypoxia-augmented chemotherapy potentiates imaging-guided combinatorial radionuclide-sonodynamic therapy for pancreatic cancer.Journal of nanobiotechnology · 2025Article
- Hydrogen Controls the Heavy Atom Roaming in Transient Negative Ion.Journal of the American Chemical Society · 2025Article
- Unraveling the Complexity of DNA Radiation Damage Using DNA Nanotechnology.Accounts of chemical research · 2024Article
- Introducing urea into tirapazamine derivatives to enhance anticancer therapy.National science review · 2024Article
- Dissociative Electron Attachment to 5-Iodo-4-thio-2'-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells.The journal of physical chemistry letters · 2023Article
- Decomposition of triazole and 3-nitrotriazole upon low-energy electron attachment.Physical chemistry chemical physics : PCCP · 2023Article
- Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2'-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment.International journal of molecular sciences · 2023Article
- Electron attachment to fluorodeoxyglucose: Dissociation dynamics in a molecule of near-zero electron affinity.The Journal of chemical physics · 2022Article
- Electron Attachment to 5-Fluorouracil: The Role of Hydrogen Fluoride in Dissociation Chemistry.International journal of molecular sciences · 2022Article
- Aptamer-Functionalized Iron-Based Metal-Organic Frameworks (MOFs) for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy.Molecules (Basel, Switzerland) · 2022Article
- Formation of Temporary Negative Ions and Their Subsequent Fragmentation upon Electron Attachment to CoQChemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- A tumor microenvironment-responsive poly(amidoamine) dendrimer nanoplatform for hypoxia-responsive chemo/chemodynamic therapy.Journal of nanobiotechnology · 2022Article
- Photoactivatable nanogenerators of reactive species for cancer therapy.Bioactive materials · 2021Review
- Negative ion formation and fragmentation upon dissociative electron attachment to the nicotinamide molecule.RSC advances · 2021Article
- Electronic structure and reactivity of tirapazamine as a radiosensitizer.Journal of molecular modeling · 2021Article
- Ring-Selective Fragmentation in the Tirapazamine Molecule upon Low-Energy Electron Attachment.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Tirapazamine (TPZ) has been tested in clinical trials on radio-chemotherapy due to its potential highly selective toxicity towards hypoxic tumor cells. It was suggested that either the hydroxyl radical or benzotriazinyl radical may form as bioactive radical after the initial reduction of TPZ in solution. In the present work, we studied low-energy electron attachment to TPZ in the gas phase and investigated the decomposition of the formed TPZ
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.