ArticleInvestigative ophthalmology & visual science2020
Alterations in the Ocular Surface Microbiome in Traumatic Corneal Ulcer Patients.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Nanosilver eye patch for ocular surface trauma: a prospective randomised trial and review of the literature.International journal of ophthalmology · 2026Article
- Exploring the ocular microecology and its role in pterygium based on metagenomics.Microbiology spectrum · 2025Article
- Preoperative conjunctival flora and antibiotic susceptibility in cataract surgery patients at Ibn Al-Haitham teaching eye hospital in Baghdad, Iraq.Journal of ophthalmic inflammation and infection · 2025Article
- Sequencing the ocular surface microbiome: a review of methodological practices and considerations.Frontiers in ophthalmology · 2025Review
- Oxford Nanopore Technology-Based Identification of anMicroorganisms · 2024Article
- The Role ofPharmaceutics · 2024Review
- Unique composition of ocular surface microbiome in the old patients with dry eye and diabetes mellitus in a community from Shanghai, China.BMC microbiology · 2024Article
- Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure.Frontiers in bioengineering and biotechnology · 2024Review
- Longitudinal Changes of Ocular Surface Microbiome in Patients Undergoing Hemopoietic Stem Cell Transplant (HSCT).Journal of clinical medicine · 2023Article
- Significantly different results in the ocular surface microbiome detected by tear paper and conjunctival swab.BMC microbiology · 2023Article
- Temporal dynamics and composition of ocular surface microbiota in C57BL/6J mice: uncovering a 12h ultradian rhythm.Frontiers in cellular and infection microbiology · 2023Article
- Alterations of the bacterial ocular surface microbiome are found in both eyes of horses with unilateral ulcerative keratitis.PloS one · 2023Article
- Topical Glaucoma Therapy Is Associated With Alterations of the Ocular Surface Microbiome.Investigative ophthalmology & visual science · 2022Article
- Effects of Sodium Hyaluronate Eye Drops With or Without Preservatives on Ocular Surface Bacterial Microbiota.Frontiers in medicine · 2022Article
- Shotgun metagenomic sequencing analysis of ocular surface microbiome in Singapore residents with mild dry eye.Frontiers in medicine · 2022Article
- Ocular surface microbiota: Ophthalmic infectious disease and probiotics.Frontiers in microbiology · 2022Review
- Comparison of the ocular surface microbiota between thyroid-associated ophthalmopathy patients and healthy subjects.Frontiers in cellular and infection microbiology · 2022Article
- Intracellular Microbiome Profiling of thePathogens (Basel, Switzerland) · 2021Article
- Strain heterogeneity, cooccurrence network, taxonomic composition and functional profile of the healthy ocular surface microbiome.Eye and vision (London, England) · 2021Article
- Conjunctival Microbiota in Patients With Type 2 Diabetes Mellitus and Influences of Perioperative Use of Topical Levofloxacin in Ocular Surgery.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Corneal ulcers are a common eye inflammatory disease that can cause visual impairment or even blindness if not treated promptly. Ocular trauma is a major risk factor for corneal ulcers, and corneal trauma in agricultural work can rapidly progress to corneal ulcers. This study aims to evaluate the changes in the ocular surface (OS) microbiome of patients with traumatic corneal ulcer (TCU). Methods: Among 20 healthy control (HC) subjects and 22 patients with TCU, 42 eyes were examined to investigate the OS microbial flora using metagenomic shotgun sequencing. Results: At the taxonomic composition level, our findings showed that dysbiosis (alterations in richness and community structure) occurs in the OS microbiome of patients with TCU. Notably, Pseudomonas was present at a greater than 30% relative abundance in all individuals in the TCU group. At the species level, the abundance of Pseudomonas fluorescens and Pseudomonas aeruginosa was significantly elevated in the TCU group compared to the HC group. At the functional level, we identified significant differences in the HC and TCU groups. We observed that inflammation-related pathways involved in bacterial chemotaxis, flagellar assembly, and biofilm formation were significantly more abundant in the TCU group. Besides, the pathways related to biosynthesis, degradation, and metabolism were also increased significantly in the TCU group. Conclusions: These findings indicate an altered OS microbiome in the affected eyes of patients with TCU. Further research is needed to determine whether these alterations contribute to the pathogenesis of TCU or impact disease progression.
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