Evidence map›Paper›PMID 32543373›Full record

ArticleeLife2020

Topologically correct synthetic reconstruction of pathogen social behavior found during

Stacie A Clark, Derek Thibault, Lauren M Shull, Kimberly M Davis, Emily Aunins, Tim van Opijnen, Ralph Isberg

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stacie A ClarkDepartment of Molecular Biology and Microbiology, Tufts University Graduate School of Biomedical Sciences, Boston, United States.ORCID 0000-0002-9638-199X
Derek ThibaultDepartment of Biology, Boston College, Boston, United States.
Lauren M ShullDepartment of Molecular Biology and Microbiology, Tufts University Graduate School of Biomedical Sciences, Boston, United States.
Kimberly M DavisW. Harry Feinstone Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health, Baltimore, United States.
Emily AuninsDepartment of Molecular Biology and Microbiology, Tufts University Graduate School of Biomedical Sciences, Boston, United States.
Tim van OpijnenDepartment of Biology, Boston College, Boston, United States.ORCID 0000-0001-6895-6795
Ralph IsbergDepartment of Molecular Biology and Microbiology, Tufts University Graduate School of Biomedical Sciences, Boston, United States.ORCID 0000-0002-8330-3554
Boston University · USBoston College · USJohns Hopkins University · US

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
MOLECULAR GENETICS OF BASIC CELL FUNCTIONST32GM007310 · NIGMS · TUFTS UNIVERSITY BOSTON · PI CAMILLI, ANDREW · 1987 to 2020
$3.9M
Mammalian cell collaboration with bacterial type III secretionR01AI110684 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2016 to 2020
$2.1M
The bacterial response to antibiotics and the evolution of antibiotic resistanceR01AI110724 · NIAID · BOSTON COLLEGE · PI VAN OPIJNEN, TIM · 2015 to 2019
$2.0M
Engineering of Complex Infectious Loci in CultureR21AI151593 · NIAID · TUFTS UNIVERSITY BOSTON · PI ISBERG, RALPH R. · 2020 to 2021
$442k
National Institute of Allergy and Infectious Diseases R21 151593NIAID NIH HHS R01 AI110684NIAID NIH HHS R01 AI110724NIAID NIH HHS R21 AI151593NIAID NIH HHS U01 AI124302NIGMS NIH HHS T32 GM007310
6 · The paper itself

Abstract

Within deep tissue sites, extracellular bacterial pathogens often replicate in clusters that are surrounded by immune cells. Disease is modulated by interbacterial interactions as well as bacterial-host cell interactions resulting in microbial growth, phagocytic attack and secretion of host antimicrobial factors. To overcome the limited ability to manipulate these infection sites, we established a system for

Indexed as

Lab-On-A-Chip DevicesMicrobial InteractionsHost-Pathogen InteractionsMacrophagesModels, BiologicalNitric OxideSocial BehaviorYersinia pseudotuberculosisNitric Oxidedropletsimmunologyinfectious diseaseinflammationmacrophagesmicrobiologymicrofluidicsnitric oxidesocial behaviorYersinia

Identifiers

PMID32543373
PMCPMC7316508
OpenAlexW3035070827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.