Evidence map›Paper›PMID 32542937›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Sensitive Morphological Characterization of Oriented High-Density Lipoprotein Nanoparticles Using

Sophie Lau, David A Middleton

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sophie LauDepartment of Chemistry, Lancaster University, Lancaster, LA1 4YB, UK.
David A MiddletonDepartment of Chemistry, Lancaster University, Lancaster, LA1 4YB, UK.ORCID 0000-0002-3227-7632

Funding

British Heart Foundation FS/15/75/31688Wellcome TrustWellcome Trust 090932/Z/09/Z
6 · The paper itself

Abstract

The biological function of high-density lipoprotein (HDL) nanoparticles, the so-called good cholesterol that is associated with a low risk of heart disease, depends on their composition, morphology, and size. The morphology of HDL particles composed of apolipoproteins, lipids and cholesterol is routinely visualised by transmission electron microscopy (TEM), but higher-resolution tools are needed to observe more subtle structural differences between particles of different composition. Here, reconstituted HDL formulations are oriented on glass substrates and solid-state

Indexed as

CholesterolLipoproteins, HDLMagnetic Resonance SpectroscopyMicroscopy, Electron, TransmissionNanoparticlesPhosphatidylcholinesPhosphorus Isotopes1-palmitoyl-2-oleoylphosphatidylcholineCholesterolLipoproteins, HDLPhosphatidylcholinesPhosphorus Isotopesapolipoprotein A-Icircular dichroismdynamic light scatteringlipidsnanoparticlesNMR spectroscopy

Identifiers

PMID32542937
PMCPMC7589421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.