ArticleAngewandte Chemie (International ed. in English)2020
TMEDA in Iron-Catalyzed Hydromagnesiation: Formation of Iron(II)-Alkyl Species for Controlled Reduction to Alkene-Stabilized Iron(0).
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 21 citations in OpenAlex.
- Synthesis and Characterization of Unusual S=1 Fe(0)-Silyl Complexes Supported by Styrene Ligands.Angewandte Chemie (International ed. in English) · 2026Article
- Iron-catalyzed stereoselective C-H alkylation for simultaneous construction of C-N axial and C-central chirality.Nature communications · 2024Article
- A TMEDA-Iron Adduct Reaction Manifold in Iron-Catalyzed C(spAngewandte Chemie (International ed. in English) · 2022Article
- Additive and Counterion Effects in Iron-Catalyzed Reactions Relevant to C-C Bond Formation.ACS catalysis · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
N,N,N',N'-Tetramethylethylenediamine (TMEDA) has been one of the most prevalent and successful additives used in iron catalysis, finding application in reactions as diverse as cross-coupling, C-H activation, and borylation. However, the role that TMEDA plays in these reactions remains largely undefined. Herein, studying the iron-catalyzed hydromagnesiation of styrene derivatives using TMEDA has provided molecular-level insight into the role of TMEDA in achieving effective catalysis. The key is the initial formation of TMEDA-iron(II)-alkyl species which undergo a controlled reduction to selectively form catalytically active styrene-stabilized iron(0)-alkyl complexes. While TMEDA is not bound to the catalytically active species, these active iron(0) complexes cannot be accessed in the absence of TMEDA. This mode of action, allowing for controlled reduction and access to iron(0) species, represents a new paradigm for the role of this important reaction additive in iron catalysis.
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Registered trials
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