ArticleAdvanced materials (Deerfield Beach, Fla.)2020
Combining Qdot Nanotechnology and DNA Nanotechnology for Sensitive Single-Cell Imaging.
Article in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Quantum Dots for Biomedical Biosensing, NIR-II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Optically switchable CLEAR probes enable rapid, biocompatible and high-efficiency fluorophore exchange for ultra-plex, high-resolution immunofluorescence imaging.Chemical science · 2026Article
- The good, the bad, and the ugly: opportunities, challenges, and pitfalls in spatial proteomics modeling.Briefings in bioinformatics · 2026Review
- Recent advances in nanomaterial-based optical biosensors and their biomedical and biopharmaceutical applications.Journal of pharmaceutical analysis · 2026Review
- Homologous targeted neutrophils-liposome system for pyroptosis-enhanced antitumor immunotherapy of triple-negative breast cancer.Materials today. Bio · 2025Article
- POSA for fast, amplified and multiplexed protein imaging.Nature communications · 2025Article
- Review
- Multiplex Immunofluorescence: A Powerful Tool in Cancer Immunotherapy.International journal of molecular sciences · 2023Review
- Preparation, applications, and challenges of functional DNA nanomaterials.Nano research · 2023Review
- Nucleotide detection mechanism and comparison based on low-dimensional materials: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection.Nature materials · 2022Article
- CODEX multiplexed tissue imaging with DNA-conjugated antibodies.Nature protocols · 2021Review
- Highly multiplexed tissue imaging using repeated oligonucleotide exchange reaction.European journal of immunology · 2021Article
- Article
- Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Immunohistochemistry (IHC) can provide detailed information about protein expression within the cell microenvironment and is one of the most common techniques in biology and medicine due to the broad availability of highly specific antibodies and well-established bioconjugation methods for modification of these antibodies with chromogens and fluorophores. Despite recent advances in this field, it remains challenging to simultaneously achieve high multiplexing, sensitivity, and throughput in single-cell profiling experiments. Here, the combination of two powerful technologies is reported, quantum dot and signal amplification by exchange reaction (QD-SABER), for sensitive and multiplexed imaging of endogenous proteins. Compared to the conventional IHC process using dye-labeled secondary antibodies (which already has a built-in signal amplification mechanism), QD-SABER provides an additional 7.6-fold signal amplification. In addition, the DNA hybridization-based IHC can be rapidly removed to regenerate the sample for subsequent cycles of immunostaining (>10 cycles), greatly expanding the multiplexing capability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.