ArticleMedical physics2021
Linear energy transfer weighted beam orientation optimization for intensity-modulated proton therapy.
Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Advances in proton therapy technology and global clinical applications.Frontiers in oncology · 2026Review
- Robust Optimization for Spot-Scanning Proton Therapy based on Dose-Linear-Energy-Transfer Volume Constraints.International journal of radiation oncology, biology, physics · 2025Article
- Enabling clinical use of linear energy transfer in proton therapy for head and neck cancer - A review of implications for treatment planning and adverse events study.Visualized cancer medicine · 2025Article
- Biological optimization for hybrid proton-photon radiotherapy.Physics in medicine and biology · 2024Article
- Hypoxia-informed RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2024Article
- Incorporating variable RBE in IMPT optimization for ependymoma.Journal of applied clinical medical physics · 2024Article
- Optimizing linear energy transfer distribution in intensity-modulated proton therapy using the alternating direction method of multipliers.Frontiers in oncology · 2024Article
- Review
- An iterative convex relaxation method for proton LET optimization.Physics in medicine and biology · 2023Article
- Reflections on beam configuration optimization for intensity-modulated proton therapy.Physics in medicine and biology · 2022Review
- A Review of Proton Therapy - Current Status and Future Directions.Precision radiation oncology · 2022Article
- Reformulated McNamara RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2022Article
- How can we consider variable RBE and LETRadiation oncology (London, England) · 2022Article
- Linear Energy Transfer and Relative Biological Effectiveness Investigation of Various Structures for a Cohort of Proton Patients With Brain Tumors.Advances in radiation oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeIn intensity-modulated proton therapy (IMPT), unaccounted-for variation in biological effectiveness contributes to the discrepancy between the constant relative biological effectiveness (RBE) model prediction and experimental observation. It is desirable to incorporate biological doses in treatment planning to improve modeling accuracy and consequently achieve a higher therapeutic ratio. This study addresses this demand by developing a method to incorporate linear energy transfer (LET) into beam orientation optimization (BOO).
methodsInstead of RBE-weighted dose, this LET weighted BOO (LETwBOO) framework uses the dose and LET product (LET
resultsThe LETwBOO plans show superior physical dose and LET
conclusionWe developed a novel LET weighted BOO method for IMPT to generate plans with improved physical and biological OAR sparing compared with the plans unaccounted for biological effects from BOO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.