Evidence map›Paper›PMID 32542627›Full record

ArticleHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2020

Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation.

Edith Klahold, Marissa Penna-Martinez, Franziska Bruns, Christian Seidl, Sabine Wicker, Klaus Badenhoop

Open access · hybridAbstract read
In one paragraph

Article in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genetic Polymorphism ofBiomolecules · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Edith KlaholdDepartment of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe-University Hospital, Frankfurt/Main, Germany.
Marissa Penna-Martinez *Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe-University Hospital, Frankfurt/Main, Germany.
Franziska BrunsDepartment of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe-University Hospital, Frankfurt/Main, Germany.
Christian SeidlGerman Red Cross Blood Donor Service, Institute for Transfusion Medicine and Immunohaematology, Frankfurt/Main, Germany.
Sabine WickerOccupational Health Service, Goethe-University Hospital, Frankfurt/Main, Germany.
Klaus Badenhoop *Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, Goethe-University Hospital, Frankfurt/Main, Germany.
University Hospital Frankfurt · DEGerman Red Cross · DEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variants of vitamin D metabolism-genes may predispose to type 2 diabetes (T2D). This study investigated the impact of these variants on disease susceptibility, Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after cholecalciferol supplementation in patients with T2D.Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped in 553 T2D patients and 916 controls. In addition 65 patients receiving either cholecalciferol or placebo were analyzed during 6 months intervention and 6 months follow-up.T2D risk alleles are VDR rs7975232 "G" (p

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseAdultAgedAged, 80 and overCase-Control StudiesCholestanetriol 26-MonooxygenaseCohort StudiesCytochrome P450 Family 2Diabetes Mellitus, Type 2Dietary SupplementsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMale25-Hydroxyvitamin D3 1-alpha-HydroxylaseCholestanetriol 26-MonooxygenaseCYP24A1 protein, humanCYP27B1 protein, humanCYP2R1 protein, humanCytochrome P450 Family 2Receptors, CalcitriolVDR protein, humanVitamin DVitamin D3 24-HydroxylaseVitamin D-Binding Protein

Identifiers

PMID32542627
PMCPMC7746514
OpenAlexW3035393333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.