ArticleDatabase : the journal of biological databases and curation2020
GTDB: an integrated resource for glycosyltransferase sequences and annotations.
Article in Database : the journal of biological databases and curation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Computational glycosyltransferases masked deoxynivalenol toxicity and halted FHB spread in wheat grains.Journal of advanced research · 2026Article
- In silico discovery of thioglycoside analogues as donor-site inhibitors of glycosyltransferase LgtC.Scientific reports · 2026Article
- Signatures of proteomics and glycoproteomics revealed liraglutide ameliorates MASLD by regulating specific metabolic homeostasis in mice.Journal of pharmaceutical analysis · 2025Article
- Comprehensive multi omics explore the microbial function in metabolic pathway flow during altered diet.NPJ science of food · 2025Article
- Leveraging core enzyme structures for microbiota targeted functional regulation: Urease as an example.iMeta · 2025Article
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- Systematic characterization of plant-associated bacteria that can degrade indole-3-acetic acid.PLoS biology · 2024Article
- The MothersBabies Study, an Australian Prospective Cohort Study Analyzing the Microbiome in the Preconception and Perinatal Period to Determine Risk of Adverse Pregnancy, Postpartum, and Child-Related Health Outcomes: Study Protocol.International journal of environmental research and public health · 2023Article
- A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland.BMC biology · 2023Article
- Ancient DNA diffuses from human bones to cave stones.iScience · 2021Article
- Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank.Microbiome · 2021Article
- Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021.Nucleic acids research · 2021Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycosyltransferases (GTs), a large class of carbohydrate-active enzymes, adds glycosyl moieties to various substrates to generate multiple bioactive compounds, including natural products with pharmaceutical or agrochemical values. Here, we first collected comprehensive information on GTs, including amino acid sequences, coding region sequences, available tertiary structures, protein classification families, catalytic reactions and metabolic pathways. Then, we developed sequence search and molecular docking processes for GTs, resulting in a GTs database (GTDB). In the present study, 520 179 GTs from approximately 21 647 species that involved in 394 kinds of different reactions were deposited in GTDB. GTDB has the following useful features: (i) text search is provided for retrieving the complete details of a query by combining multiple identifiers and data sources; (ii) a convenient browser allows users to browse data by different classifications and download data in batches; (iii) BLAST is offered for searching against pre-defined sequences, which can facilitate the annotation of the biological functions of query GTs; and lastly, (iv) GTdock using AutoDock Vina performs docking simulations of several GTs with the same single acceptor and displays the results based on 3Dmol.js allowing easy view of models.
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