Evidence map›Paper›PMID 32542110›Full record

ArticleComputational and structural biotechnology journal2020

Rewired functional regulatory networks among miRNA isoforms (isomiRs) from let-7 and miR-10 gene families in cancer.

Tingming Liang, Leng Han, Li Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. LNA-Probe-Based MicroRNA In Situ Hybridization in Brain Organoids.Methods in molecular biology (Clifton, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Tingming LiangJiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, China.
Leng HanDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030, USA.
Li GuoDepartment of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, China.
Nanjing Normal University · CNNanjing University of Posts and Telecommunications · CNThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical microRNA (miRNA) has been so far believed as a single sequence, but it indeed contains multiple miRNA isoforms (isomiR) with various sequences and expression patterns. It is not clear whether these diverse isomiRs have potential relationships and whether they contribute to miRNA:mRNA interactions. Here, we aimed to reveal the potential evolutionary and functional relationships of multiple isomiRs based on let-7 and miR-10 gene families that are prone to clustering together on chromosomes. Multiple isomiRs within gene families showed similar functions to their canonical miRNAs, indicating selection of the predominant sequence. IsomiRs containing novel seed regions showed increased/decreased biological function depending on whether they had more/less specific target mRNAs than their annotated seed. Few gene ontology(GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were shared among the target genes of the annotated seeds and the novel seeds. Various let-7 isomiRs with novel seed regions may cause opposing drug responses despite the fact that they are generated from the same miRNA locus and have highly similar sequences. IsomiRs, especially the dominant isomiRs with shifted seeds, may disturb the coding-non-coding RNA regulatory network. These findings provide insight into the multiple isomiRs and isomiR-mediated control of gene expression in the pathogenesis of cancer.

Indexed as

ACC, adrenocortical carcinomaBLCA, bladder urothelial carcinomaBRCA, breast invasive carcinomaCESC, cervical squamous cell carcinoma and endocervical adenocarcinomaCHOL, cholangiocarcinomaCOAD, colon adenocarcinomaESCA, esophageal carcinomaFunctionGBM, glioblastoma multiformeHNSC, head and neck squamous cell carcinomaIsomiRKICH, kidney chromophobeKIRC, kidney renal clear cell carcinomaKIRP, kidney renal papillary cell carcinomaLAML, acute myeloid leukemiaLet-7LGG, brain Lower grade gliomaLIHC, liver hepatocellular carcinomaLUAD, lung adenocarcinomaLUSC, lung squamous cell carcinomaMESO, mesotheliomaMicroRNA (miRNA)miR-10NetworkOV, ovarian serous cystadenocarcinomaPAAD, pancreatic adenocarcinomaPCPG, pheochromocytoma and paragangliomaPRAD, prostate adenocarcinomaREAD, rectum adenocarcinomaSARC, sarcomaSKCM, skin cutaneous melanomaSTAD, stomach adenocarcinomaTGCT, testicular germ cell tumorsTHCA, thyroid carcinomaTHYM, thymomaTSG, tumor suppressor geneUCEC, uterine corpus endometrial carcinomaUCS, uterine carcinosarcomaUVM, uveal melanoma

Identifiers

PMID32542110
PMCPMC7280754
OpenAlexW3025279674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.