ArticlePloS one2020
Use of microwave ablation for thermal treatment of solid tumors with different shapes and sizes-A computational approach.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Image-Based Monitoring of Thermal Ablation.Bioengineering (Basel, Switzerland) · 2025Review
- Safety and Effectiveness of Triple-Antenna Hepatic Microwave Ablation.Bioengineering (Basel, Switzerland) · 2024Article
- Temperature Simulation of an Ablation Needle for the Prediction of Tissue Necrosis during Liver Ablation.Journal of clinical medicine · 2024Article
- Microwave Thermal Ablation for Breast Cancer in Africa: A Pioneering Case Report Utilizing TATOpro.Cureus · 2024Article
- Using Patient-Specific 3D Modeling and Simulations to Optimize Microwave Ablation Therapy for Liver Cancer.Cancers · 2024Article
- Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model.IEEE open journal of engineering in medicine and biology · 2024Article
- Review
- A Survey of the Thermal Analysis of Implanted Antennas for Wireless Biomedical Devices.Micromachines · 2023Review
- 3D modeling of vector/edge finite element method for multi-ablation technique for large tumor-computational approach.PloS one · 2023Article
- Numerical Estimation of SAR and Temperature Distributions inside Differently Shaped Female Breast Tumors during Radio-Frequency Ablation.Materials (Basel, Switzerland) · 2022Article
- MWA Performed at 5.8 GHz through 'Side Firing' Approach: An Exploratory Study.Sensors (Basel, Switzerland) · 2022Article
- Computational Modeling of Microwave Tumor Ablation.Bioengineering (Basel, Switzerland) · 2022Review
- Efficacy and safety of microwave ablation for benign breast lesions: a systematic review and meta-analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Review
- An Analysis of Microwave Ablation Parameters for Treatment of Liver Tumors from the 3D-IRCADb-01 Database.Biomedicines · 2022Article
- Computational Modeling of Combination of Magnetic Hyperthermia and Temperature-Sensitive Liposome for Controlled Drug Release in Solid Tumor.Pharmaceutics · 2021Article
- On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma.Cancers · 2021Article
- Applications of Microwave Energy in Medicine.Biosensors · 2021Review
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microwave Ablation (MWA) is one of the most recent developments in the field of thermal therapy. This approach is an effective method for thermal tumor ablation by increasing the temperature above the normal physiological threshold to kill cancer cells with minimum side effects to surrounding organs due to rapid heat dispersive tissues. In the present study, the effects of the shape and size of the tumor on MWA are investigated. To obtain the temperature gradient, coupled bio-heat and electromagnetic equations are solved using a three-dimensional finite element method (FEM). To extract cellular response at different temperatures and times, the three-state mathematical model was employed to achieve the ablation zone size. Results show that treatment of larger tumors is more difficult than that of smaller ones. By doubling the diameter of the tumor, the percentage of dead cancer cells is reduced by 20%. For a spherical tumor smaller than 2 cm, applying 50 W input power compared to 25 W has no significant effects on treatment efficiency and only increases the risk of damage to adjacent tissues. However, for tumors larger than 2 cm, it can increase the ablation zone up to 21%. In the spherical and oblate tumors, the mean percentage of dead cells at 6 GHz is nearly 30% higher than that at 2.45GHz, but for prolate tumors, treatment efficacy is reduced by 10% at a higher frequency. Moreover, the distance between two slots in the coaxial double slot antenna is modified based on the best treatment of prolate tumors. The findings of this study can be used to choose the optimum frequency and the best antenna design according to the shape and size of the tumor.
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