Evidence map›Paper›PMID 32541975›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2020

[Effect of benzo(a)pyrene on dopaminergic neurons and α-synuclein in brain and its mechanism involved].

Y Z Qi, H H Quan, W X Xu, Q R Li, H Zhou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Y Z QiDepartment of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.
H H QuanDepartment of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.
W X XuDepartment of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.
Q R LiDepartment of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.
H ZhouDepartment of Occupational and Environmental Health, Peking University School of Public Health, Beijing 100191, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the effect of benzopyrene on the decrease of dopaminergic neurons, and the increase and aggregation of α-synuclein, which are the pathological features of Parkinson's disease, and to explore its possible mechanisms.

methodsEight-month-old transgenic mice with human

resultsAfter BaP exposure, the movement time of the mice in the rotarod test was significantly reduced (

conclusionBaP exposure not only inhibited function of neurotransmitter receptor and dopamine transporter, but also interfered cell autophagy, thereby hindering the degradation of α-synuclein, which could lead to decrease of dopaminergic neurons in substantia nigra and increase and aggregation of α-synuclein in midbrain, as the significant pathology of Parkinson's disease. Therefore, BaP exposure may increase the risk of Parkinson's disease.

Indexed as

Dopaminergic Neuronsalpha-SynucleinAnimalsBenzo(a)pyreneBrainDopamineHumansMicealpha-SynucleinBenzo(a)pyreneDopamineAlpha-synucleinBenzo(a)pyreneDopaminergic neuronsParkinson’s disease

Identifiers

PMID32541975
PMCPMC7433417
OpenAlexW3035614161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.