Evidence map›Paper›PMID 32541957›Full record

ArticleNature biotechnology2020

A lipidome atlas in MS-DIAL 4.

Hiroshi Tsugawa, Kazutaka Ikeda, Mikiko Takahashi, Aya Satoh, Yoshifumi Mori, Haruki Uchino, Nobuyuki Okahashi, Yutaka Yamada, Ipputa Tada, Paolo Bonini and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 450 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
450citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

450 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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390 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hiroshi TsugawaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan. hiroshi.tsugawa@riken.jp.ORCID http://orcid.org/0000-0002-2015-3958
Kazutaka IkedaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Mikiko TakahashiRIKEN Center for Sustainable Resource Science, Yokohama, Japan.ORCID http://orcid.org/0000-0002-4529-2284
Aya SatohRIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Yoshifumi MoriBruker, Yokohama, Japan.
Haruki UchinoRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-1204-5436
Nobuyuki OkahashiRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yutaka YamadaRIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Ipputa TadaDepartment of Genetics, The Graduate University for Advanced Studies, SOKENDAI, Miura, Japan.
Paolo BoniniNGAlab, Tarragona, Spain.ORCID http://orcid.org/0000-0001-5379-2265
Yasuhiro HigashiRIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Yozo OkazakiRIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Zhiwei ZhouInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Zheng-Jiang ZhuInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0002-3272-3567
Jeremy KoelmelDepartment of Pathology, University of Florida, Gainsville, FL, USA.
Tomas CajkaInstitute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-9728-3355
Oliver FiehnWest Coast Metabolomics Center, UC Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-6261-8928
Kazuki SaitoRIKEN Center for Sustainable Resource Science, Yokohama, Japan.ORCID http://orcid.org/0000-0001-6310-5342
Masanori AritaRIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Makoto AritaRIKEN Center for Integrative Medical Sciences, Yokohama, Japan. makoto.arita@riken.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present Mass Spectrometry-Data Independent Analysis software version 4 (MS-DIAL 4), a comprehensive lipidome atlas with retention time, collision cross-section and tandem mass spectrometry information. We formulated mass spectral fragmentations of lipids across 117 lipid subclasses and included ion mobility tandem mass spectrometry. Using human, murine, algal and plant biological samples, we annotated and semiquantified 8,051 lipids using MS-DIAL 4 with a 1-2% estimated false discovery rate. MS-DIAL 4 helps standardize lipidomics data and discover lipid pathways.

Indexed as

Data AnalysisChromatography, LiquidLipidomicsLipidsTandem Mass SpectrometryLipids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.