ArticleNature microbiology2020
FOXO1 promotes HIV latency by suppressing ER stress in T cells.
Open access · greenAbstract read
In one paragraph
Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation.Cell reports · 2026Article
- Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation.Journal of virology · 2026Article
- Article
- HIV-induced T cell quiescence and the origins of viral latency.Nature immunology · 2025Article
- Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells.Journal of virus eradication · 2025Article
- Host-directed approaches in the pursuit of a cure for HIV.Antiviral research · 2025Review
- HIV-1 latency: From acquaintance to confidant.Journal of virus eradication · 2025Review
- Heat shock protein 90 is a chaperone regulator of HIV-1 latency.PLoS pathogens · 2025Article
- Identification of key genes associated with idiopathic pulmonary fibrosis and sarcopenia by bioinformatics analysis.PloS one · 2025Article
- Integrated bioinformatics analysis identifies hub genes and immune regulatory networks in HIV infection.Frontiers in immunology · 2025Article
- Article
- Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation.Genomics, proteomics & bioinformatics · 2024Article
- Review
- ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor.Biology · 2024Review
- Review
- Article
- Selective ablation of 3' RNA ends and processive RTs facilitate direct cDNA sequencing of full-length host cell and viral transcripts.Nucleic acids research · 2022Article
- The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products.Antioxidants (Basel, Switzerland) · 2022Review
- SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.PLoS pathogens · 2022Article
- SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.bioRxiv : the preprint server for biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 2 countries.
Albert Vallejo-GraciaGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA.
Irene P Chen *Gladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA.
Rosalba Perrone *The Buck Institute for Research on Aging, Novato, CA, USA.
Emilie BesnardThe Buck Institute for Research on Aging, Novato, CA, USA.
Daniela BoehmGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA.
Emilie BattivelliThe Buck Institute for Research on Aging, Novato, CA, USA.
Tugsan TezilThe Buck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0003-0796-3718
Karsten KreyGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1280-4722
Kyle A RaymondVitalant Research Institute, San Francisco, CA, USA.
Philip A HullGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA.
Marius WalterThe Buck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0002-2476-9661
Ireneusz HabryloGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA.
Andrew CruzThe Buck Institute for Research on Aging, Novato, CA, USA.
Steven DeeksUniversity of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6371-747X
Satish PillaiUniversity of California San Francisco, San Francisco, CA, USA.
Eric VerdinUniversity of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3703-3183
Melanie OttGladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, CA, USA. mott@gladstone.ucsf.edu.ORCID http://orcid.org/0000-0002-5697-1274
Buck Institute for Research on Aging · USGladstone Institutes · USUniversity of California, San Francisco · USPacific Research Institute · US
Funding
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MMolecular Mechanisms of HIV LatencyR01DA041742 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI VERDIN, ERIC M. · 2016 to 2021
$6.5MRole of Factor Acetylation in the Regulation of HIV TranscriptionR37AI083139 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Melanie Maria Ott · 2019 to 2026
$5.5MA new model of accelerated immune aging in HIV-infected drug usersDP1DA038043 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2014 to 2019
$4.8MRole of Factor Acetylation in the Regulation of HIV TranscriptionR01AI083139 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2009 to 2017
$3.9MIdentification of HIV latency biomarkers with a dual fluorescence reporter HIVR01AI117864 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI VERDIN, ERIC M. · 2015 to 2020
$3.5MEffects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV LatencyR01GM117901 · NIGMS · VITALANT · PI PILLAI, SATISH KUMAR · 2015 to 2018
$1.5MEffects of Cell-Intrinsic Immunity on Establishment and Reversal of HIV LatencyR01AI150449 · NIAID · VITALANT · PI PILLAI, SATISH KUMAR · 2019 to 2019
$305kNIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI083139NIAID NIH HHS R01 AI117864NIAID NIH HHS R01 AI150449NIAID NIH HHS R37 AI083139NIDA NIH HHS DP1 DA038043NIDA NIH HHS R01 DA041742NIGMS NIH HHS R01 GM117901NIGMS NIH HHS T32 GM007618
Abstract
Quiescence is a hallmark of CD4
Indexed as
Activating Transcription Factor 4CD4-Positive T-LymphocytesEndoplasmic Reticulum StressForkhead Box Protein O1Gene Knockdown TechniquesHIV-1HIV InfectionsHumansK562 CellsVirus ActivationVirus LatencyActivating Transcription Factor 4ATF4 protein, humanForkhead Box Protein O1FOXO1 protein, human
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.