Evidence map›Paper›PMID 32541946›Full record

ArticleNature microbiology2020

Exosome mimicry by a HAVCR1-NPC1 pathway of endosomal fusion mediates hepatitis A virus infection.

Maria Isabel Costafreda, Abdolrahim Abbasi, Hsinyi Lu, Gerardo Kaplan

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  8. Therapeutic, preventive, and pathogenetic advances in viral hepatitis.Frontiers in cellular and infection microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maria Isabel CostafredaFood and Drug Administration, Center for Biologics Evaluation and Research, Office of Blood Research and Review, Silver Spring, MD, USA.ORCID http://orcid.org/0000-0002-3114-3034
Abdolrahim AbbasiFood and Drug Administration, Center for Biologics Evaluation and Research, Office of Blood Research and Review, Silver Spring, MD, USA.
Hsinyi LuFood and Drug Administration, Center for Biologics Evaluation and Research, Office of Blood Research and Review, Silver Spring, MD, USA.
Gerardo KaplanFood and Drug Administration, Center for Biologics Evaluation and Research, Office of Blood Research and Review, Silver Spring, MD, USA. gerardo.kaplan@fda.hhs.gov.ORCID http://orcid.org/0000-0003-3303-7259
Center for Biologics Evaluation and Research · US

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Cell-to-cell communication by exosomes controls normal and pathogenic processes

Indexed as

Carrier ProteinsCell LineCRISPR-Cas SystemsEbolavirusEndocytosisEndosomesExosomesGene Knockout TechniquesHEK293 CellsHepatitis AHepatitis A virusHepatitis A Virus Cellular Receptor 1HumansIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteinCarrier ProteinsHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Intracellular Signaling Peptides and ProteinsMembrane GlycoproteinsNiemann-Pick C1 ProteinNPC1 protein, humanViral Fusion Proteins

Identifiers

PMID32541946
PMCPMC7483988
OpenAlexW3035365113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.