Evidence map›Paper›PMID 32541899›Full record

ArticleScientific reports2020

Gene-signature-derived IC

Steffen Renner, Christian Bergsdorf, Rochdi Bouhelal, Magdalena Koziczak-Holbro, Andrea Marco Amati, Valerie Techer-Etienne, Ludivine Flotte, Nicole Reymann, Karen Kapur, Sebastian Hoersch and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Steffen RennerChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland. steffen.renner@novartis.com.
Christian BergsdorfChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
Rochdi BouhelalChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
Magdalena Koziczak-HolbroMusculoskeletal, NIBR, Basel, Switzerland.
Andrea Marco AmatiChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
Valerie Techer-EtienneChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
Ludivine FlotteMusculoskeletal, NIBR, Basel, Switzerland.
Nicole ReymannChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
Karen KapurNIBR Informatics, NIBR, Basel, Switzerland.
Sebastian HoerschNIBR Informatics, NIBR, Basel, Switzerland.
Edward James OakeleyASI, NIBR, Basel, Switzerland.
Ansgar SchuffenhauerChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
Hanspeter GublerNIBR Informatics, NIBR, Basel, Switzerland.
Eugen LounkineChemical Biology & Therapeutics, NIBR, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Pierre FarmerChemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland. pierre.farmer@novartis.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiplexed gene-signature-based phenotypic assays are increasingly used for the identification and profiling of small molecule-tool compounds and drugs. Here we introduce a method (provided as R-package) for the quantification of the dose-response potency of a gene-signature as EC

Indexed as

Adrenergic beta-AgonistsCell Line, TumorCell ProliferationCyclic AMPDose-Response Relationship, DrugErbB ReceptorsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInhibitory Concentration 50NeoplasmsPhenotypeSignal TransductionTHP-1 CellsAdrenergic beta-AgonistsCyclic AMPEGFR protein, humanErbB Receptors

Identifiers

PMID32541899
PMCPMC7295968

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.