Evidence map›Paper›PMID 32541825›Full record

ArticleScientific reports2020

Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7-9 year old rural Gambian children.

Kim Maasen, Philip T James, Andrew M Prentice, Sophie E Moore, Caroline H Fall, Giriraj R Chandak, Modupeh Betts, Matt J Silver, Jessica L Buxton

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Kim MaasenDivision of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Philip T JamesDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Andrew M PrenticeMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, Banjul, The Gambia.
Sophie E MooreMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, Banjul, The Gambia.
Caroline H FallMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
Giriraj R ChandakGenomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Modupeh BettsMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, Banjul, The Gambia.
Matt J Silver *Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, Banjul, The Gambia. Matt.Silver@lshtm.ac.uk.
Jessica L Buxton *Genetics and Genomic Medicine Programme, UCL Great Ormond Street Institute of Child Health, London, UK. J.Buxton@kingston.ac.uk.
MRC Unit the Gambia · GMUniversity College London · GBCentre for Cellular and Molecular Biology · INKing's College London · GBLondon School of Hygiene & Tropical Medicine · GBMaastricht University Medical Centre · NLMRC Lifecourse Epidemiology Unit · GB

Funding

Medical Research Council G0400519Medical Research Council MC-A760- 5QX00Medical Research Council MC_EX_MR/M01424X/1Medical Research Council MC_PC_MR/R020183/1Medical Research Council MC_U123292700Medical Research Council MC_U123292701Medical Research Council MC_UP_1005/1Medical Research Council MC_UP_A620_1016Medical Research Council MC_UU_00026/3Medical Research Council MC_UU_12011/3Medical Research Council MR/N006208/1Medical Research Council MR/P012019/1
6 · The paper itself

Abstract

Early life exposures are important predictors of adult disease risk. Although the underlying mechanisms are largely unknown, telomere maintenance may be involved. This study investigated the relationship between seasonal differences in parental exposures at time of conception and leukocyte telomere length (LTL) in their offspring. LTL was measured in two cohorts of children aged 2 yrs (N = 487) and 7-9 yrs (N = 218). The association between date of conception and LTL was examined using Fourier regression models, adjusted for age, sex, leukocyte cell composition, and other potential confounders. We observed an effect of season in the older children in all models [likelihood ratio test (LRT) χ²

Indexed as

Telomere ShorteningChildChild, PreschoolCross-Sectional StudiesFemaleFertilizationGambiaHumansLeukocytesMaleRegression AnalysisSeasonsTelomere

Identifiers

PMID32541825
PMCPMC7295801
OpenAlexW3034944602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.