ArticleObstetrics and gynecology2020
Early Pregnancy Blood Pressure Elevations and Risk for Maternal and Neonatal Morbidity.
Article in Obstetrics and gynecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- American College of Cardiology and American Heart Association blood pressure categories-a systematic review of the relationship with adverse pregnancy outcomes in the first half of pregnancy.American journal of obstetrics and gynecology · 2023Pooled it
- Perinatal Outcomes Associated With Management of Stage 1 Hypertension.Obstetrics and gynecology · 2023Trial
- Article
- Maternal kidney adaptation and function in pregnancy: review and perspectives.Function (Oxford, England) · 2026Review
- Preeclampsia Screening.Diagnostics (Basel, Switzerland) · 2026Review
- Pregnancy adverse outcomes associated with change of blood pressure categories in early pregnancy among women with normotension: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Association Between Prepregnancy Blood Pressure and Reproductive Outcomes of In Vitro Fertilization.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Sex-specific association between maternal integrative endocrine and metabolic status during pregnancy and preschoolers' emotional-behavioral development: A birth cohort study.European child & adolescent psychiatry · 2026Article
- Nomogram for predicting postpartum hemorrhage in women with hypertensive disorders of pregnancy.Scientific reports · 2025Article
- Do lower antenatal blood pressure cut-offs in pregnant women with obesity identify those at greater risk of adverse maternal and perinatal outcomes? A secondary analysis of data from the UK Pregnancies Better Eating and Activity Trial (UPBEAT).International journal of obesity (2005) · 2025Article
- Early pregnancy triglycerides and blood pressure: a combined predictor for preeclampsia.BMC pregnancy and childbirth · 2025Article
- Impact of stage 1 hypertension before 20 gestational weeks on pregnancy outcomes in twin pregnancies: a retrospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Outpatient Portal Use and Blood Pressure Management during Pregnancy.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- Diagnostic properties of differing BP thresholds for adverse pregnancy outcomes in standard-risk nulliparous women: A secondary analysis of SCOPE cohort data.PLoS medicine · 2025Article
- Qualineo Strategy Indicators Associated with Neonatal Death: A Cross-Sectional Study.International journal of environmental research and public health · 2024Article
- Perinatal outcomes in women with lower-range elevated blood pressure and stage 1 hypertension: insights from the Kaya health and demographic surveillance system, Burkina Faso.BMC public health · 2023Article
- Characteristics of Premature Myocardial Infarction Among Women With Prior Adverse Pregnancy Outcomes.JACC. Advances · 2023Article
- What we talk about when we talk about severe maternal morbidity: a call to action to critically review severe maternal morbidity as an outcome measure.American journal of obstetrics & gynecology MFM · 2023Article
- Evidence of Nitric Oxide Impairment During Hypertensive Pregnancies.Advances in experimental medicine and biology · 2023Review
- Pregnancy Outcomes in Females with Stage 1 Hypertension and Elevated Blood Pressure Undergoing In Vitro Fertilization and Embryo Transfer.Journal of clinical medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo investigate whether women with early pregnancy elevated blood pressure (BP) or stage 1 hypertension exhibit increased risk of preeclampsia and maternal or neonatal morbidity.
methodsWe conducted a clinical cohort study of 18,162 women who delivered a singleton neonate from 2015 to 2018 and attended at least two prenatal appointments before 20 weeks of gestation. Data were collected within the Magee Obstetric Maternal and Infant database, an aggregate of prenatal and delivery health records. Early pregnancy BP was defined as average BP before 20 weeks of gestation, and women were classified with normal, elevated BP, stage 1 or 2 hypertension according to current guidelines. The primary outcome was preeclampsia. Secondary outcomes were severe maternal morbidity, placental abruption, gestational diabetes, and composite neonatal morbidity.
resultsOverall, 75.2% of the women were categorized with normal BP, 13.9% with elevated BP, 5.4% with stage 1 hypertension, and 5.5% with stage 2 hypertension. Risk of preeclampsia increased in a stepwise fashion with increasing BP category, adjusted for covariates (normal BP, 4.7%, referent; elevated BP, 7.3%, adjusted odds ratio [aOR] 1.29, 95% CI 1.07-1.56; stage 1, 12.3%, aOR 2.35, 95% CI 1.86-2.96), and stage 2, 30.2%, aOR 6.49, 95% CI 5.34-7.89). Results were similar among black and white women. Gestational diabetes was more prevalent among women with stage 1 (11.4%; aOR 1.50, 95% CI 1.18-1.91] and stage 2 hypertension (14.2%; aOR 1.65, 95% CI 1.30-2.10). Severe maternal morbidity and neonatal morbidity were increased only among women with stage 2 hypertension (aOR 2.99, 95% CI 2.26-3.99, and aOR 2.67, 95% CI 2.28-3.12, respectively).
conclusionWomen with elevated BP, and stage 1 and 2 hypertension in early pregnancy are at increased risk for preeclampsia. These findings emphasize the importance of applying the 2017 BP guidelines to reproductive-aged women. Strategies to incorporate these guidelines into obstetric care may also be warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.