Evidence map›Paper›PMID 32541073›Full record

ArticleThe Journal of rheumatology2021

Inflammatory Bowel Disease in Children With Systemic Juvenile Idiopathic Arthritis.

Justine Maller, Emily Fox, K T Park, Sarah Sertial Paul, Kevin Baszis, Charlotte Borocco, Sampath Prahalad, Pierre Quartier, Adam Reinhardt, Dieneke Schonenberg-Meinema and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Juvenile idiopathic arthritis.Nature reviews. Disease primers · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 5 countries.

Justine MallerJ. Maller, MD, PhD, Department of Pediatrics, Division of Rheumatology, Stanford University School of Medicine, Stanford, California, USA.ORCID http://orcid.org/0000-0001-6930-7375
Emily FoxE. Fox, MD, Department of Pediatrics, Division of Rheumatology, Stanford University School of Medicine, Stanford, California, and Department of Pediatrics, Division of Rheumatology, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, Missouri, USA.ORCID http://orcid.org/0000-0003-2360-8556
K T ParkK.T. Park, MD, Department of Pediatrics, Division of Gastroenterology, Stanford University School of Medicine, Stanford, California, USA.
Sarah Sertial PaulS. Sertial Paul, DO, Department of Pediatrics, Goryeb Children's Hospital, Morristown, New Jersey, USA.
Kevin BaszisK. Baszis, MD, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID http://orcid.org/0000-0002-5854-0216
Charlotte BoroccoC. Borocco, MD, Paris University, Imagine Institute and Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital, AP-HP, Paris, France.ORCID http://orcid.org/0000-0002-2310-7930
Sampath PrahaladS. Prahalad, MD, Department of Pediatrics and Department of Genetics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0003-3489-1756
Pierre QuartierP. Quartier, MD, Paris University, Imagine Institute, RAISE Reference Centre and Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital, AP-HP, Paris, France.ORCID http://orcid.org/0000-0002-1769-549X
Adam ReinhardtA. Reinhardt, MD, Department of Pediatrics, Boys Town National Research Hospital, Omaha, Nebraska, USA.
Dieneke Schonenberg-MeinemaD. Schonenberg-Meinema, MD, Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Amsterdam Universitair Medische Centra, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9416-6631
Lauren Shipman-DuensingL. Shipman-Duensing, MD, Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Maria Teresa TerreriM.T. Terreri, MD, Department of Pediatrics, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2496-4296
Julia SimardJ. Simard, ScD, Department of Health Research & Policy, Division of Epidemiology, and Department of Medicine, Division of Immunology & Rheumatology, Stanford University, Stanford, California, USA.ORCID http://orcid.org/0000-0001-5735-9856
Idit LaviI. Lavi, MA, Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
Elizabeth ChalomE. Chalom, MD, Department of Pediatrics, Saint Barnabas Medical Center, Livingston, New Jersey, USA.
Joyce HsuJ. Hsu, MD, Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.
Devy ZismanD. Zisman, MD, Carmel Medical Center, Rheumatology Unit, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.ORCID http://orcid.org/0000-0003-0523-2292
Elizabeth D MellinsE.D. Mellins, MD, Department of Pediatrics, Division of Human Gene Therapy, Program in Immunology, Stanford University School of Medicine, Stanford, California, USA. mellins@stanford.edu.ORCID http://orcid.org/0000-0003-2577-139X
CARRA Legacy Registry Investigators
Stanford University · USAssistance Publique – Hôpitaux de Paris · FRCarmel Medical Center · ILAmsterdam University Medical Centers · NLBoys Town National Research Hospital · USChildren's Mercy Hospital · USEmory University · USGoryeb Children's Hospital · USSaint Barnabas Medical Center · USUniversidade Federal de São Paulo · BRUniversity of Alabama at Birmingham · USWashington University in St. Louis · US

Funding

CARRA: Accelerating Toward an Evidence Based Culture in Pediatric RheumatologyRC2AR058934 · NIAMS · DUKE UNIVERSITY · PI ILOWITE, NORMAN T, SANDBORG, CHRISTY IRENE · 2009 to 2010
$6.8M
Training Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6M
NIAMS NIH HHS RC2 AR058934NIAMS NIH HHS T32 AR050942
6 · The paper itself

Abstract

objectiveThe incidence of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) is higher than in the general pediatric population. However, reports of IBD in the systemic JIA (sJIA) subtype are limited. We sought to characterize sJIA patients diagnosed with IBD and to identify potential contributing risk factors.

methodsUsing an internationally distributed survey, we identified 16 patients with sJIA who were subsequently diagnosed with IBD (sJIA-IBD cohort). Five hundred twenty-two sJIA patients without IBD were identified from the CARRA Legacy Registry and served as the sJIA-only cohort for comparison. Differences in demographic, clinical characteristics, and therapy were assessed using chi-square test, Fisher exact test,

resultsOf the patients with sJIA-IBD, 75% had a persistent sJIA course and 25% had a history of macrophage activation syndrome. sJIA-IBD subjects were older at sJIA diagnosis, more often non-White, had a higher rate of IBD family history, and were more frequently treated with etanercept or canakinumab compared to sJIA-only subjects. Sixty-nine percent of sJIA-IBD patients successfully discontinued sJIA medications following IBD diagnosis, and sJIA symptoms resolved in 9 of 12 patients treated with tumor necrosis factor-α (TNF-α) inhibitors.

conclusionIBD in the setting of sJIA is a rare occurrence. The favorable response of sJIA symptoms to therapeutic TNF-α inhibition suggests that the sJIA-IBD cohort may represent a mechanistically distinct sJIA subgroup. Our study highlights the importance of maintaining a high level of suspicion for IBD when gastrointestinal involvement occurs in patients with sJIA and the likely broad benefit of TNF-α inhibition in those cases.

Indexed as

Arthritis, JuvenileInflammatory Bowel DiseasesMacrophage Activation SyndromeChildEtanerceptHumansRegistriesEtanerceptautoinflammationcytokine inhibitorsinflammatory bowel diseasepediatric rheumatologysystemic juvenile idiopathic arthritis

Identifiers

PMID32541073
PMCPMC7736056
OpenAlexW3035235510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.