ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Integrity of Corpus Callosum Is Essential for theCross-Hemispheric Propagation of Sleep Slow Waves:A High-Density EEG Study in Split-Brain Patients.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
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- Classifying Sleep Slow Oscillations in Low Density EEG.Neuroinformatics · 2026Article
- Sleep loss induces cholesterol-associated myelin dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hemispheric disparity theory: a dual-system framework for consciousness.Frontiers in psychology · 2026Article
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- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Network-specific corpus callosum aging and age-moderated cognitive associations using tract-to-region analysis.Communications biology · 2025Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Research square · 2025Article
- Photosensitivity of an aging brain.bioRxiv : the preprint server for biology · 2025Article
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- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.bioRxiv : the preprint server for biology · 2025Article
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- The first-night effect of sleep occurs over nonconsecutive nights in unfamiliar and familiar environments.Sleep · 2024Article
- Sleep disorders in pediatric patients with agenesis of the corpus callosum.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Proof-of-concept evidence for high-density EEG investigation of sleep slow wave traveling in First-Episode Psychosis.Scientific reports · 2024Article
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Authors and funding
16 authors at 4 institutions in 4 countries.
Funding
Abstract
The slow waves of non-rapid eye movement (NREM) sleep reflect experience-dependent plasticity and play a direct role in the restorative functions of sleep. Importantly, slow waves behave as traveling waves, and their propagation is assumed to occur through cortico-cortical white matter connections. In this light, the corpus callosum (CC) may represent the main responsible for cross-hemispheric slow-wave propagation. To verify this hypothesis, we performed overnight high-density (hd)-EEG recordings in five patients who underwent total callosotomy due to drug-resistant epilepsy (CPs; two females), in three noncallosotomized neurologic patients (NPs; two females), and in a sample of 24 healthy adult subjects (HSs; 13 females). In all CPs slow waves displayed a significantly reduced probability of cross-hemispheric propagation and a stronger inter-hemispheric asymmetry. In both CPs and HSs, the incidence of large slow waves within individual NREM epochs tended to differ across hemispheres, with a relative overall predominance of the right over the left hemisphere. The absolute magnitude of this asymmetry was greater in CPs relative to HSs. However, the CC resection had no significant effects on the distribution of slow-wave origin probability across hemispheres. The present results indicate that CC integrity is essential for the cross-hemispheric traveling of slow waves in human sleep, which is in line with the assumption of a direct relationship between white matter integrity and slow-wave propagation. Our findings also revealed a residual cross-hemispheric slow-wave propagation that may rely on alternative pathways, including cortico-subcortico-cortical loops. Finally, these data indicate that the lack of the CC does not lead to differences in slow-wave generation across brain hemispheres.
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