ArticleMolecular & cellular proteomics : MCP2020
Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.
Open access · hybridAbstract read
In one paragraph
Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Comparative Interactome Analysis Reveals Architectural Principles Governing KInternational journal of molecular sciences · 2026Article
- Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3.Nature communications · 2026Article
- Targeting protein protein interactions and their modulators to enable new therapeutic strategies for human diseases.NPJ systems biology and applications · 2026Review
- Intermediate Conductance Calcium-Dependent Potassium Channel (KJournal of cellular physiology · 2025Article
- Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome.Cell discovery · 2025Review
- BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.Science advances · 2024Article
- The network of cardiac KNaunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Proteomics of the heart.Physiological reviews · 2024Review
- The Kir2.1E299V mutation increases atrial fibrillation vulnerability while protecting the ventricles against arrhythmias in a mouse model of short QT syndrome type 3.Cardiovascular research · 2024Article
- Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1.Molecular medicine (Cambridge, Mass.) · 2024Article
- Article
- Unraveling Impacts of Chamber-Specific Differences in Intercalated Disc Ultrastructure and Molecular Organization on Cardiac Conduction.JACC. Clinical electrophysiology · 2023Article
- Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil syndrome.Cardiovascular research · 2023Article
- Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram.Nature cardiovascular research · 2023Article
- Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen-Tawil syndrome type 1.Nature cardiovascular research · 2022Article
- Detecting Cardiovascular Protein-Protein Interactions by Proximity Proteomics.Circulation research · 2022Review
- Proteomic Analysis of the Functional Inward Rectifier Potassium Channel (Kir) 2.1 Reveals Several Novel Phosphorylation Sites.Biochemistry · 2021Article
- Use of Proximity Labeling in Cardiovascular Research.JACC. Basic to translational science · 2021Review
- Deciphering molecular interactions by proximity labeling.Nature methods · 2021Review
- Inwardly Rectifying Potassium Channel Kir2.1 and its "Kir-ious" Regulation by Protein Trafficking and Roles in Development and Disease.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 2 countries.
Sung-Soo ParkDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Daniela Ponce-BalbuenaDepartment of Internal Medicine and Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Rork KuickDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Guadalupe Guerrero-SernaDepartment of Internal Medicine and Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Justin YoonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-3387-3508
Dattatreya MellacheruvuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Kevin P ConlonDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Venkatesha BasrurDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-0853-9655
Alexey I NesvizhskiiDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-2806-7819
José JalifeDepartment of Internal Medicine and Center for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA jrual@umich.edu jjalife@umich.edu.
Jean-François RualDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA jrual@umich.edu jjalife@umich.edu.ORCID 0000-0003-4465-8819
University of Michigan · US
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2MCOMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATAR01GM094231 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 2010 to 2026
$5.4MUniversity of Michigan Proteogenomics Data Analysis CenterU24CA210967 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, DHANASEKARAN, SARAVANA M · 2016 to 2020
$4.1MIntermolecular Interactions of NaV1.5 and Kir2.1 In Ion Channel DiseasesR01HL122352 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2015 to 2018
$1.9MNCI NIH HHS P30 CA046592NCI NIH HHS U24 CA210967NHLBI NIH HHS R01 HL122352NIGMS NIH HHS R01 GM094231
Abstract
Kir2.1, a strong inward rectifier potassium channel encoded by the
Indexed as
Protein Interaction MapsAction PotentialsAndersen SyndromeChromatography, LiquidDesmosomesHEK293 CellsHumansLysosomesMolecular ChaperonesMutationMyocytes, CardiacPatch-Clamp TechniquesPlakophilinsPotassiumPotassium Channels, Inwardly RectifyingProtein TransportKir2.1 channelMolecular Chaperonesnascent-polypeptide-associated complexPKP4 protein, humanPlakophilinsPotassiumPotassium Channels, Inwardly RectifyingSomatomedinsUTRN protein, humanUtrophinBioIDcardiomyopathycardiovascular diseasecardiovascular function or biologyinward rectifier potassium currentKir2.1macromolecular complex analysismass spectrometryPKP4Protein-protein interactions*
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.