ArticleJournal of immunology (Baltimore, Md. : 1950)2020
Hypercapnia Suppresses Macrophage Antiviral Activity and Increases Mortality of Influenza A Infection via Akt1.
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In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of Permissive Hypercapnia During Lung Surgery on Inflammatory Biomarkers in Serum and Bronchoalveolar Lavage Fluid: A Randomized Controlled Trial.Metabolites · 2026Article
- Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026Review
- The ribosomal landscape in influenza A virus infection: from molecular mechanisms to clinical relevance.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Role of the DPP4 Receptor in SARS-CoV Entry: Insights From Docking and Molecular Dynamics Simulations.Proteins · 2025Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
- Hypercapnia Increases Influenza A Virus Infection of Bronchial Epithelial Cells by Augmenting Cellular Cholesterol via mTOR and Akt.International journal of molecular sciences · 2025Article
- Identifying Daytime Hypercapnia Using Transcutaneous Carbon Dioxide Monitoring in Patients With Amyotrophic Lateral Sclerosis.Muscle & nerve · 2025Article
- Rapamycin improves satellite cells' autophagy and muscle regeneration during hypercapnia.JCI insight · 2025Article
- Contribution of the bitter taste signaling pathway to lung inflammation duringFrontiers in immunology · 2025Article
- Influence of the spaceflight environment on macrophage lineages.NPJ microgravity · 2024Review
- Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus.JCI insight · 2024Article
- Lowering PRespiratory care · 2023Article
- Practical Guide to Management of Long-Term Noninvasive Ventilation for Adults With Chronic Neuromuscular Disease.Respiratory care · 2023Review
- Association between the time-varying arterial carbon dioxide pressure and 28-day mortality in mechanically ventilated patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2023Article
- Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol.Frontiers in immunology · 2023Article
- Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure.Chest · 2023Observational
- Development of a humanized HLA-A30 transgenic mouse model.Animal models and experimental medicine · 2022Article
- Hypercapnia in COPD: Causes, Consequences, and Therapy.Journal of clinical medicine · 2022Review
- Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage.Interface focus · 2021Article
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
S Marina Casalino-MatsudaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; marinamatsuda@northwestern.edu.ORCID 0000-0002-7566-4560
Fei ChenDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Francisco J Gonzalez-GonzalezDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Aisha NairDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-9575-3077
Sandra DibDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0001-9648-270X
Alex YemelyanovDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Khalilah L GatesDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-3114-5208
Greg J BeitelDepartment of Molecular Biosciences, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208.ORCID 0000-0003-4413-6324
Peter H S SpornDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-1006-9437
Northwestern University · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MNorthwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Irina Budunova · 2019 to 2026
$6.6MHypercapnia and Suppression of Anti-viral Host DefenseR01HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2017 to 2019
$1.2MHypercapnia and Suppression of Anti-viral Host DefenseR56HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2016 to 2016
$391kNCATS NIH HHS UL1 TR001422NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL131745NHLBI NIH HHS R56 HL131745NIAMS NIH HHS P30 AR075049NIA NIH HHS P01 AG049665
Abstract
Hypercapnia (HC), elevation of the partial pressure of CO
Indexed as
AnimalsCells, CulturedGene Expression RegulationHumansHypercapniaImmunity, CellularImmunosuppression TherapyInfluenza A virusInfluenza, HumanLungMacrophage ActivationMacrophagesMiceMice, Inbred C57BLOncogene Protein v-aktOrthomyxoviridae InfectionsOncogene Protein v-akt
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.