Evidence map›Paper›PMID 32540971›Full record

ArticleAntimicrobial agents and chemotherapy2020

Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant Mycobacterium tuberculosis.

Keira A Cohen, Katharine E Stott, Vanisha Munsamy, Abigail L Manson, Ashlee M Earl, Alexander S Pym

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
0.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 54 citations in OpenAlex.

  1. Pharmacological assessment of drugs retained in the 1Naunyn-Schmiedeberg's archives of pharmacology · 2026
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  14. Computational and structural biotechnology journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Keira A CohenDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA kcohen8@jhmi.edu.ORCID 0000-0002-4521-397X
Katharine E StottAntimicrobial Pharmacodynamics and Therapeutics, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Vanisha MunsamyAfrica Health Research Institute (AHRI), Durban, South Africa.
Abigail L MansonBroad Institute of Harvard and M.I.T., Cambridge, Massachusetts, USA.ORCID 0000-0002-3800-0714
Ashlee M EarlBroad Institute of Harvard and M.I.T., Cambridge, Massachusetts, USA.
Alexander S PymAfrica Health Research Institute (AHRI), Durban, South Africa.
Africa Health Research Institute · ZABroad Institute · USJohns Hopkins University · USUniversity of Liverpool · GB

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI BIRREN, BRUCE W., NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
Improved Tools for Nontuberculous Mycobacteria Lung DiseaseK08HL139994 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI COHEN, KEIRA ALEXIS · 2018 to 2022
$794k
NHLBI NIH HHS K08 HL139994NIAID NIH HHS HHSN272200900018CNIAID NIH HHS U19 AI110818Wellcome Trust
6 · The paper itself

Abstract

In 2019, the WHO tuberculosis (TB) treatment guidelines were updated to recommend only limited use of streptomycin, in favor of newer agents or amikacin as the preferred aminoglycoside for drug-resistant

Indexed as

Mycobacterium tuberculosisPharmaceutical PreparationsTuberculosis, Multidrug-ResistantAntitubercular AgentsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsMutationPhylogenySouth AfricaStreptomycinAntitubercular AgentsPharmaceutical PreparationsStreptomycinaminoglycosidesdrug resistance mechanismsmultidrug resistanceMycobacterium tuberculosistuberculosiswhole-genome sequencing

Identifiers

PMID32540971
PMCPMC7449167
OpenAlexW3035383363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.