ArticleLearning & memory (Cold Spring Harbor, N.Y.)2020
Reducing shock imminence eliminates poor avoidance in rats.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Safety Signals Enable Single-Episode Active Avoidance paradigm and Expose Threat Generalization in Tuberous Sclerosis Complex.bioRxiv : the preprint server for biology · 2026Article
- Article
- Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus.Nature communications · 2024Article
- A sex-specific role for the bed nucleus of the stria terminalis in proactive defensive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Spontaneous instrumental avoidance learning in social contexts.Scientific reports · 2022Article
- The central nucleus of the amygdala and the construction of defensive modes across the threat-imminence continuum.Nature neuroscience · 2022Review
- The effect of stress and exercise on the learning performance of horses.Scientific reports · 2022Article
- Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors.Nature neuroscience · 2021Article
- Fear, defense, and emotion: A neuroethological understanding of the negative valence research domain criteria.The American psychologistArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In signaled active avoidance (SigAA), rats learn to suppress Pavlovian freezing and emit actions to remove threats and prevent footshocks. SigAA is critical for understanding aversively motivated instrumental behavior and anxiety-related active coping. However, with standard protocols ∼25% of rats exhibit high freezing and poor avoidance. This has dampened enthusiasm for the paradigm and stalled progress. We demonstrate that reducing shock imminence with long-duration warning signals leads to greater freezing suppression and perfect avoidance in all subjects. This suggests that instrumental SigAA mechanisms evolved to cope with distant harm and protocols that promote inflexible Pavlovian reactions are poorly designed to study avoidance.
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Registered trials
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