Evidence map›Paper›PMID 32540869›Full record

ArticleInfection and immunity2020

Nontypeable Haemophilus influenzae Type IV Pilus Mediates Augmented Adherence to Rhinovirus-Infected Human Airway Epithelial Cells.

Stephen L Toone, Michelle Ratkiewicz, Laura A Novotny, Binh L Phong, Lauren O Bakaletz

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. The rhinovirus puzzle: Linking virus and host factors to childhood asthma.The Journal of allergy and clinical immunology · 2026
    Review
  4. Article
  5. Review
  6. Biofilm aggregates and the host airway-microbial interface.Frontiers in cellular and infection microbiology · 2022
    Review
  7. NontypeableBiofilm · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Stephen L TooneCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Michelle RatkiewiczPediatric Pulmonology, Phoenix Children's Hospital, Phoenix, Arizona, USA.
Laura A NovotnyCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Binh L PhongCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Lauren O BakaletzCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA lauren.bakaletz@nationwidechildrens.org.ORCID 0000-0002-0017-1710
Nationwide Children's Hospital · USPhoenix Children's Hospital · US

Funding

DETERMINANTS OF H. INFLUENZAE VIRULENCE IN OTITIS MEDIAR01DC003915 · NIDCD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI GOODMAN, STEVEN D · 1999 to 2025
$12.5M
NIDCD NIH HHS R01 DC003915
6 · The paper itself

Abstract

Human rhinovirus (hRV) is frequently detected in the upper respiratory tract, and symptomatic infection is associated with an increased nasopharyngeal bacterial load, with subsequent development of secondary bacterial diseases. Nontypeable

Indexed as

Adhesins, BacterialAntibodies, NeutralizingAntigens, CDBacterial AdhesionCell Adhesion MoleculesEpithelial CellsFimbriae ProteinsGene Expression RegulationHaemophilus influenzaeHost-Pathogen InteractionsHumansIntercellular Adhesion Molecule-1Primary Cell CultureProtein BindingRespiratory MucosaRhinovirusAdhesins, BacterialAntibodies, NeutralizingAntigens, CDCD66 antigensCell Adhesion MoleculesFimbriae ProteinsICAM1 protein, humanIntercellular Adhesion Molecule-1RNA, MessengercoinfectionHAEPilAvaccine

Identifiers

PMID32540869
PMCPMC7440766
OpenAlexW3034732642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.