Evidence map›Paper›PMID 32540854›Full record

ArticleCancer research2020

TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma.

Alejandro Parrales, Tomoo Iwakuma

Open access · greenAbstract readComment
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alejandro ParralesDepartment of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas.
Tomoo IwakumaDepartment of Cancer Biology, University of Kansas Medical Center, Kansas City, Kansas. tiwakuma@kumc.edu.
The University of Kansas Cancer Center · US

Funding

Control of mutant p53 stability via the mevalonate pathway-DNAJA1 axisR01CA214916 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI IWAKUMA, TOMOO · 2018 to 2022
$1.8M
The role of MDM2-MTBP axis in cancer metastasisR01CA174735 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI IWAKUMA, TOMOO · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA174735NCI NIH HHS R01 CA214916
6 · The paper itself

Abstract

Despite increasing incidence rates, prognosis of invasive cutaneous squamous cell carcinoma remains poor, mainly due to lack of reliable molecular markers that can be used for targeted therapy. Through genetic and proteogenomic analyses, Davis and colleagues in this issue of

Indexed as

Carcinoma, Squamous CellMicroRNAsSkin NeoplasmsAnimalsAurora Kinase ACell Line, TumorHumansMiceAURKA protein, humanAurora Kinase AMicroRNAsMIRN497 microRNA, human

Identifiers

PMID32540854
PMCPMC9284287
OpenAlexW3035272509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.