Evidence map›Paper›PMID 32540629›Full record

ArticleNeuroImage. Clinical2020

Altered subcortical emotional salience processing differentiates Parkinson's patients with and without psychotic symptoms.

F Knolle, S Garofalo, R Viviani, A Justicia, A O Ermakova, H Blank, G B Williams, G Arrondo, P Ramachandra, C Tudor-Sfetea and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 5 countries.

F KnolleDepartment of Psychiatry, University of Cambridge, Cambridge, UK; Department of Neuroradiology, Technical University Munich, Munich, Germany. Electronic address: franziska.knolle@tum.de.
S GarofaloUniversity of Bologna, Department of Psychology, Bologna, Italy.
R VivianiInstitute of Psychology, University of Innsbruck, Innsbruck, Austria; Psychiatry and Psychotherapy Clinic III, University of Ulm, Ulm, Germany.
A JusticiaDepartment of Psychiatry, University of Cambridge, Cambridge, UK; IMIM (Hospital del Mar Medical Research Institute), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain.
A O ErmakovaFaculty of Natural Sciences, Imperial College London, UK.
H BlankInstitute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
G B WilliamsDepartment of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
G ArrondoDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
P RamachandraCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
C Tudor-SfeteaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
N BunzeckInstitute of Psychology I, University of Lübeck, Lübeck, Germany.
E DuezelOtto-von-Guericke University Magdeburg, Institute of Cognitive Neurology and Dementia Research, Magdeburg, Germany; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
T W RobbinsDepartment of Psychology, University of Cambridge, Cambridge, UK.
R A BarkerDepartment of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
G K MurrayDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
University of Cambridge · GBWellcome/MRC Cambridge Stem Cell Institute · GBCambridgeshire and Peterborough NHS Foundation Trust · GBGerman Center for Neurodegenerative Diseases · DEImperial College London · GBUniversität Hamburg · DEUniversität Innsbruck · ATUniversity of Bologna · ITUniversity of Lübeck · DE

Funding

Department of HealthMedical Research Council G0701911
6 · The paper itself

Abstract

objectiveCurrent research does not provide a clear explanation for why some patients with Parkinson's Disease (PD) develop psychotic symptoms. The 'aberrant salience hypothesis' of psychosis has been influential and proposes that dopaminergic dysregulation leads to inappropriate attribution of salience to irrelevant/non-informative stimuli, facilitating the formation of hallucinations and delusions. The aim of this study is to investigate whether non-motivational salience is altered in PD patients and possibly linked to the development of psychotic symptoms.

methodsWe investigated salience processing in 14 PD patients with psychotic symptoms, 23 PD patients without psychotic symptoms and 19 healthy controls. All patients were on dopaminergic medication for their PD. We examined emotional salience using a visual oddball fMRI paradigm that has been used to investigate early stages of schizophrenia spectrum psychosis, controlling for resting cerebral blood flow as assessed with arterial spin labelling fMRI.

resultsWe found significant differences between patient groups in brain responses to emotional salience. PD patients with psychotic symptoms had enhanced brain responses in the striatum, dopaminergic midbrain, hippocampus and amygdala compared to patients without psychotic symptoms. PD patients with psychotic symptoms showed significant correlations between the levels of dopaminergic drugs they were taking and BOLD signalling, as well as psychotic symptom scores.

conclusionOur study suggests that enhanced signalling in the striatum, dopaminergic midbrain, the hippocampus and amygdala is associated with the development of psychotic symptoms in PD, in line with that proposed in the 'aberrant salience hypothesis' of psychosis in schizophrenia.

Indexed as

AdultAgedAmygdalaBrainDiagnosis, DifferentialEmotionsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseasePsychotic DisordersSchizophrenia

Identifiers

PMID32540629
PMCPMC7298672
OpenAlexW3030668479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.