Evidence map›Paper›PMID 32540577›Full record

ArticleThe Journal of surgical research2020

Liver Transplantation in Patients with Sickle Cell Disease in the United States.

Rachel Hogen, Michelle Kim, Yelim Lee, Mary Lo, Navpreet Kaur, Jeff Kahn, Shefali Chopra, Yasir Qazi, Ashraf Sedra, Jim Kim and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Emerging need for a hepato-hematology program for patients with sickle cell disease in Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Article
  4. Liver Transplant for Acute Cholestatic Crisis in Sickle Cell Disease.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
  5. The role of mitochondria in iron overload-induced damage.Journal of translational medicine · 2024
    Review
  6. Article
  7. Review
  8. Treatment and outcomes of hepatocellular carcinoma in patients with Sickle cell disease: a population-based study in the U.S.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Rachel HogenDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
Michelle KimDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
Yelim LeeCalifornia Institute of Technology, Pasadena, California.
Mary LoDepartment of Preventive Medicine, University of Southern California, Los Angeles, California.
Navpreet KaurDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
Jeff KahnDepartment of Laboratory Medicine and Pathology, University of Southern California, Los Angeles, California.
Shefali ChopraDepartment of Laboratory Medicine and Pathology, University of Southern California, Los Angeles, California.
Yasir QaziDepartment of Medicine, University of Southern California, Los Angeles, California.
Ashraf SedraDepartment of Anesthesiology, University of Southern California, Los Angeles, California.
Jim KimDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
Lauren O'BrienDepartment of Laboratory Medicine and Pathology, University of Southern California, Los Angeles, California.
Yuri GenykDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
Linda SherDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California.
Juliet EmamaulleeDivision of Hepatobiliary and Abdominal Organ Transplant Surgery, Department of Surgery, University of Southern California, Los Angeles, California. Electronic address: Juliet.emamaullee@med.usc.edu.
University of Southern California · USCalifornia Institute of Technology · US

Funding

Structural and Functional Studies of the Uterine LymphaticsR01HL141857 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Young-Kwon Hong · 2018 to 2026
$3.6M
NHLBI NIH HHS R01 HL141857
6 · The paper itself

Abstract

backgroundUp to 30% of patients with sickle cell disease (SCD) develop chronic liver disease via etiologies including sickle cell hepatopathy, acquired viral hepatitis, or secondary hemochromatosis. It is unclear how many patients with SCD ultimately undergo liver transplantation (LT) and what factors are associated with survival after LT. In this study, we examined LT outcomes in these patients by reviewing the Scientific Registry of Transplant Recipients (SRTR) and our institutional experience.

methodsAnalysis of the SRTR identified 23 LT recipients and five simultaneous liver and kidney transplantation (SLKT) recipients with SCD. Patient demographics and graft and patient survival were analyzed. Two patients with SCD at our institution underwent SLKT.

resultsReview of the SRTR revealed that recipients with SCD had significantly higher model for end-stage liver disease scores (33 versus 21, P = 0.004), preoperative intensive care unit admission (43.5% versus 19.1%, P = 0.007), preoperative dialysis (17.4% versus 4.9%, P = 0.009), and were more likely to be status 1 (26.1% versus 12.1%, P = 0.041) when compared with the reference population of African American LT recipients. Despite being higher risk at the time of LT, patients with SCD had equivalent posttransplant graft and patient survival when compared with the reference population (P = 0.5 and P = 0.2, respectively) and a 2:1 propensity score-matched group (P = 0.5 and P = 0.2, respectively). Two recent SLKT recipients with SCD from our institution have performed well with stable allograft function.

conclusionsData from the SRTR demonstrate that patients with SCD can expect equivalent graft and patient survival after LT despite exhibiting more comorbidities at the time of LT. The low number of patients with SCD who underwent LT in the SRTR in comparison with the rate of chronic liver disease in this population raises the question as to whether a disparity in access to LT exists for this complex population.

Indexed as

AdolescentAdultAnemia, Sickle CellBlack or African AmericanChildChild, PreschoolEnd Stage Liver DiseaseFemaleGraft SurvivalHealthcare DisparitiesHumansKidney Failure, ChronicKidney TransplantationLiver TransplantationMaleMiddle AgedHealth disparitiesLiver transplantationScientific registry of transplant recipientsSickle cell disease

Identifiers

PMID32540577
PMCPMC7541438
OpenAlexW3034255594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.