ArticleJournal of hepatology2020
Blocking integrin α
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Article in Journal of hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
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Who cites it
63 citing papers in PubMed, 77 citations in OpenAlex.
- The gut-liver axis in drug-induced liver injury (DILI): Interplay between gut microbiota, intestinal barrier, and immune system.Acta pharmaceutica Sinica. B · 2026Review
- MASH-Associated T Cell Activation and Neuroinflammation: Evidence for a Hepatosystemic Immune Axis.Seminars in liver disease · 2026Review
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- The Role of Kupffer Cells and Liver Macrophages in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease.Biomedicines · 2026Review
- Myokine-mediated mechanisms of immune checkpoint inhibitors-associated colorectal injury and repair in rectal cancer.Frontiers in immunology · 2026Review
- Integrin α4β7: Pathogenic Roles in Metabolic and Inflammatory Diseases and Translational Therapeutics.Journal of inflammation research · 2026Review
- From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs.Frontiers in immunology · 2026Review
- Association between mental health and MASLD molecular insights through metabolomics.Communications medicine · 2025Article
- Advances in the acting mechanism and treatment of gut microbiota in metabolic dysfunction-associated steatotic liver disease.Gut microbes · 2025Review
- Review
- Beyond Discrete Diagnoses: Conceptualizing Obesity-associated Metabolic Disorders as a Unified, Dynamic Continuum.Current obesity reports · 2025Review
- The Role and Application of MAdCAM-1/α4β7-Induced Lymphocyte Migration in Inflammatory Enterohepatic Diseases.Biomedicines · 2025Review
- Advances in ligand-based surface engineering strategies for fine-tuning T cell mechanotransduction toward efficient immunotherapy.Biophysical journal · 2025Review
- Review
- C/EBPβ-VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD.JHEP reports : innovation in hepatology · 2025Article
- Inflammation in MASLD progression and cancer.JHEP reports : innovation in hepatology · 2025Review
- Bile acids and their receptors in hepatic immunity.Liver research (Beijing, China) · 2025Review
- Single-Cell Data Analysis Reveals Critical Hepatic Cells Subpopulations in the Progression of Non-alcoholic Fatty Liver Disease to Non-Alcoholic Steatohepatitis.Combinatorial chemistry & high throughput screening · 2025Article
- Immunometabolic integration in therapeutic strategies for managing MASLD.Frontiers in pharmacology · 2025Review
- Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells byFrontiers in pharmacology · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Ravi P RaiDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Yunshan LiuDivision of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
Smita S IyerCenter for Comparative Medicine, School of Veterinary Medicine, University of California, Davis, CA, USA; California National Primate Research Center, University of California, Davis, CA, USA; Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA, USA.
Silvia LiuDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
Biki GuptaDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Chirayu DesaiDepartment of Biological Sciences, P. D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Gujarat, India.
Pradeep KumarDivision of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
Tekla SmithDivision of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
Aatur D SinghiPittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Anatomic Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Asma NusratDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Charles A ParkosDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Satdarshan P MongaDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Mark J CzajaDivision of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.
Frank A AnaniaDivision of Gastroenterology and Inborn Error Products, Food and Drug Administration, Silver Spring, MD, USA.
Reben RaemanDivision of Experimental Pathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: reben.raeman@pitt.edu.
University of Pittsburgh · USEmory University · USUniversity of Michigan · USCharotar University of Science and Technology · INUnited States Food and Drug Administration · USUniversity of California, Davis · US
Funding
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gavin E Arteel · 2019 to 2026
$10.9MRole of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0MMODULATION OF ACUTE TOXIC LIVER INJURYR01DK044234 · NIDDK · YESHIVA UNIVERSITY · PI SRINIVASAN, SHANTHI K · 1992 to 2023
$7.6MNeutrophil Interactions with Intestinal Epithelial CellsR01DK072564 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2005 to 2020
$6.5MStructure-Function Studies on Intestinal Epithelial JAMR01DK061379 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PARKOS, CHARLES A · 2002 to 2021
$6.3MYap and beta-catenin interactions in liver: Implications in PathophysiologyR01CA204586 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, XIN, MONGA, SATDARSHAN SINGH · 2016 to 2020
$2.1MDefects in junctional adhesion molecule-A and Intestinal Permeability: Identification of Novel Mechanisms Driving Non-Alcoholic SteatohepatitisR01DK111678 · NIDDK · EMORY UNIVERSITY · PI CZAJA, MARK J · 2017 to 2020
$1.9MTargeting beta-catenin in liver pathology: Novel Interactions, Novel ParadigmsR01DK100287 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MONGA, SATDARSHAN SINGH · 2013 to 2016
$1.3MTargeting CD4 TFH cells to enhance HIV vaccine-induced humoral immunityK01OD023034 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2016 to 2018
$1.0MRole of CD4 T cells in the pathogenesis of non-alcoholic steatohepatitisK01DK110264 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAEMAN, REBEN · 2017 to 2021
$702kRole of female genital mucosa associated CD4 T cells in vaccine-induced HIV susceptibilityR21AI143454 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IYER, SWAMINATHAN SMITA · 2019 to 2020
$623kNCI NIH HHS R01 CA204586NIAID NIH HHS R03 AI138792NIAID NIH HHS R21 AI143454NIDDK NIH HHS K01 DK110264NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK120531NIDDK NIH HHS R01 DK044234NIDDK NIH HHS R01 DK061379NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK072564NIDDK NIH HHS R01 DK100287NIDDK NIH HHS R01 DK111678NIH HHS K01 OD023034
Abstract
BACKGROUND &
aimsThe heterodimeric integrin receptor α
methodsMale littermate F11r
resultsWD-fed knockout mice developed NASH and had increased hepatic and intestinal α
conclusionsThese findings establish α LAY SUMMARY: Non-alcoholic steatohepatitis (NASH) is an advanced and progressive form of non-alcoholic fatty liver disease (NAFLD), and despite its growing incidence no therapies currently exist to halt NAFLD progression. Herein, we show that blocking integrin receptor α
Indexed as
AnimalsAntibodies, MonoclonalCD4-Positive T-LymphocytesCell Adhesion MoleculesDiet, WesternDisease Models, AnimalGastrointestinal MicrobiomeHumansIntegrinsIntestinal MucosaLiverMaleMiceMice, KnockoutMucoproteinsNon-alcoholic Fatty Liver DiseaseAntibodies, MonoclonalCell Adhesion MoleculesF11r protein, mouseintegrin alpha4beta7IntegrinsMADCAM1 protein, humanMadcam1 protein, mouseMucoproteinsReceptors, Cell SurfaceRNA, Ribosomal, 16SEpithelial barrierGut permeabilityInflammationMicrobiotaNon-alcoholic fatty liver disease
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.