Evidence map›Paper›PMID 32540036›Full record

SynthesisSurgery2020

Decision analysis and reinforcement learning in surgical decision-making.

Tyler J Loftus, Amanda C Filiberto, Yanjun Li, Jeremy Balch, Allyson C Cook, Patrick J Tighe, Philip A Efron, Gilbert R Upchurch, Parisa Rashidi, Xiaolin Li and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tyler J LoftusDepartment of Surgery, University of Florida Health, Gainesville, FL.
Amanda C FilibertoDepartment of Surgery, University of Florida Health, Gainesville, FL.
Yanjun LiNSF Center for Big Learning, University of Florida, Gainesville, FL.
Jeremy BalchDepartment of Surgery, University of Florida Health, Gainesville, FL.
Allyson C CookDepartment of Medicine, University of California, San Francisco, CA.
Patrick J TigheDepartments of Anesthesiology, Orthopedics, and Information Systems/Operations Management, University of Florida Health, Gainesville, FL.
Philip A EfronDepartment of Surgery, University of Florida Health, Gainesville, FL.
Gilbert R UpchurchDepartment of Surgery, University of Florida Health, Gainesville, FL.
Parisa RashidiDepartments of Biomedical Engineering, Computer and Information Science and Engineering, and Electrical and Computer Engineering, University of Florida, Gainesville, FL; Precision and Intelligence in Medicine, Department of Medicine, University of Florida Health, Gainesville, FL.
Xiaolin LiNSF Center for Big Learning, University of Florida, Gainesville, FL.
Azra BihoracDepartment of Medicine, University of California, San Francisco, CA; Precision and Intelligence in Medicine, Department of Medicine, University of Florida Health, Gainesville, FL. Electronic address: abihorac@ufl.edu.

Funding

PICS: A New Horizon for Surgical Critical CareP50GM111152 · NIGMS · UNIVERSITY OF FLORIDA · PI MOORE, FREDERICK A · 2014 to 2018
$10.7M
Integrating data, algorithms and clinical reasoning for surgical risk assessmentR01GM110240 · NIGMS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2016 to 2025
$5.1M
Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Finding Good TEMporal PostOperative pain Signatures (TEMPOS)R01GM114290 · NIGMS · UNIVERSITY OF FLORIDA · PI TIGHE, PATRICK J · 2015 to 2019
$2.5M
Autonomous Pain Recognition in Non-Verbal and Critically Ill PatientsR21EB027344 · NIBIB · UNIVERSITY OF FLORIDA · PI RASHIDI, PARISA · 2019 to 2022
$577k
NIBIB NIH HHS R21 EB027344NIGMS NIH HHS P50 GM111152NIGMS NIH HHS R01 GM110240NIGMS NIH HHS R01 GM114290NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

backgroundSurgical patients incur preventable harm from cognitive and judgment errors made under time constraints and uncertainty regarding patients' diagnoses and predicted response to treatment. Decision analysis and techniques of reinforcement learning theoretically can mitigate these challenges but are poorly understood and rarely used clinically. This review seeks to promote an understanding of decision analysis and reinforcement learning by describing their use in the context of surgical decision-making.

methodsCochrane, EMBASE, and PubMed databases were searched from their inception to June 2019. Included were 41 articles about cognitive and diagnostic errors, decision-making, decision analysis, and machine-learning. The articles were assimilated into relevant categories according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines.

resultsRequirements for time-consuming manual data entry and crude representations of individual patients and clinical context compromise many traditional decision-support tools. Decision analysis methods for calculating probability thresholds can inform population-based recommendations that jointly consider risks, benefits, costs, and patient values but lack precision for individual patient-centered decisions. Reinforcement learning, a machine-learning method that mimics human learning, can use a large set of patient-specific input data to identify actions yielding the greatest probability of achieving a goal. This methodology follows a sequence of events with uncertain conditions, offering potential advantages for personalized, patient-centered decision-making. Clinical application would require secure integration of multiple data sources and attention to ethical considerations regarding liability for errors and individual patient preferences.

conclusionTraditional decision-support tools are ill-equipped to accommodate time constraints and uncertainty regarding diagnoses and the predicted response to treatment, both of which often impair surgical decision-making. Decision analysis and reinforcement learning have the potential to play complementary roles in delivering high-value surgical care through sound judgment and optimal decision-making.

Indexed as

Clinical Decision-MakingDecision Support TechniquesMachine LearningSurgical Procedures, OperativeAttitude to HealthDecision Making, SharedDecision TreesElectronic Health RecordsHumansNumbers Needed To TreatPatient-Centered CarePatient Preference

Identifiers

PMID32540036
PMCPMC7390703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.