Observational studyCardiovascular diabetology2020
Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study.
Observational study in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Effect of continuous positive airway pressure on ventricular remodeling of patients with combined diabetes mellitus and obstructive sleep apnea: a cross-sectional study and follow-on randomized clinical trial.International journal of cardiology · 2025Trial
- Impact of empagliflozin on right ventricular parameters and function among patients with type 2 diabetes.Cardiovascular diabetology · 2021Trial
- Right ventricular dysfunction in type 1 diabetic cardiomyopathy: An overlooked component?World journal of diabetes · 2026Article
- Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study.World journal of diabetes · 2025Article
- The Contribution of Echocardiography to the Diagnosis and Prognosis Stratification of Diabetic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2025Review
- Association of the triglyceride‒glucose index with subclinical right ventricular systolic dysfunction in type 2 diabetes mellitus patients.Scientific reports · 2025Article
- Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study.Cardiovascular diabetology · 2025Article
- Type 2 diabetes mellitus and cardiovascular health: Evidence of causal relationships in a European ancestry population.ESC heart failure · 2024Article
- The right ventricular dysfunction and ventricular interdependence in patients with T2DM and aortic regurgitation: an assessment using CMR feature tracking.Cardiovascular diabetology · 2024Article
- Improvements of myocardial strain and work in diabetes patients with normal ejection fraction after empagliflozin treatment.Journal of diabetes investigation · 2024Article
- Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes.Cardiovascular diabetology · 2023Article
- The right ventricular dysfunction and ventricular interdependence in patients with DM: assessment using cardiac MR feature tracking.Cardiovascular diabetology · 2023Article
- Heart Failure Association-International Cardio-Oncology Society Risk Score Validation in HER2-Positive Breast Cancer.Journal of clinical medicine · 2023Article
- Impact of glycemic control on biventricular function in patients with type 2 diabetes mellitus: a cardiac magnetic resonance tissue tracking study.Insights into imaging · 2023Article
- Impact of T2DM on right ventricular systolic dysfunction and interventricular interactions in patients with essential hypertension: evaluation using CMR tissue tracking.Cardiovascular diabetology · 2022Article
- Review
- Effects of Lipid Overload on Heart in Metabolic Diseases.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2021Review
- Association of left ventricular longitudinal myocardial function with subclinical right ventricular dysfunction in type 2 diabetes mellitus.Cardiovascular diabetology · 2021Article
- Diabetes Mellitus and Heart Failure.Journal of clinical medicine · 2021Review
- Prevention of Diabetes and Cardiovascular Disease in Obesity.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsThe role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.
methodsParticipants of the Maastricht Study; a population-based cohort study (426 normal glucose metabolism (NGM), 142 prediabetes, 224 diabetes), underwent two-dimensional and tissue Doppler echocardiography. Multiple linear regression analyses with pairwise comparisons of (pre)diabetes versus NGM, adjusted for cardiovascular risk factors, and mediation analyses were used.
resultsIn general, differences were small. Nevertheless, in individuals with prediabetes and diabetes compared to NGM; RA volume index was lower (both p < 0.01, p
conclusions(Pre)diabetes is associated with structural RA and RV changes, and impaired RV systolic and diastolic function, independent of cardiovascular risk factors. These associations were largely not mediated by indices of LV structure, LV function or pulmonary pressure. This suggests that (pre)diabetes affects RA and RV structure and function due to direct myocardial involvement.
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