ArticleBMC infectious diseases2020
Clinical and computed tomography features of extended-spectrum β-lactamase-producing Klebsiella pneumoniae liver abscess.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Hypervirulent Klebsiella pneumoniae Infections: A Systematic Review of Clinical, Microbiological, and Outcome Data From Reported Cases.MicrobiologyOpen · 2026Pooled it
- Multimodal ultrasound in the diagnosis and treatment of caudate lobe Klebsiella pneumoniae liver abscess complicated by rare gas-containing inferior vena cava thrombosis: a case report.BMC infectious diseases · 2026Article
- A machine learning-based online prediction model for recurrence risk in patients withFrontiers in cellular and infection microbiology · 2026Article
- Predictive factors for liver abscess liquefaction degree based on clinical, laboratory, and computed tomography data.World journal of gastrointestinal surgery · 2025Article
- Analysis of clinical characteristics of elderly patients with blood culture-positive bacterial liver abscess.Frontiers in medicine · 2025Article
- Clinical Characteristics and Risk Factors for Blood Culture-Positive Klebsiella pneumoniae Liver Abscess: A Retrospective Study.International medical case reports journal · 2025Article
- Development and validation of a clinical-radiomics nomogram for the early prediction of Klebsiella pneumoniae liver abscess.Annals of medicine · 2024Article
- Liver abscess in the caudate lobe caused by Klebsiella pneumoniae: a rare case report and literature review.BMC infectious diseases · 2024Review
- Antibiotic treatment durations for pyogenic liver abscesses: A systematic review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023Article
- Comprehensive analysis of the microbiome and metabolome in pus from pyogenic liver abscess patients with and without diabetes mellitus.Frontiers in microbiology · 2023Article
- Association of blood culture with carbapenem use in pyogenic liver abscess: a two-center retrospective study.BMC emergency medicine · 2021Observational
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4 authors at 1 institution in 1 country.
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Abstract
backgroundKlebsiella pneumoniae (KP) is the primary pathogen associated with pyogenic liver abscesses (PLAs). Moreover, there has been an increase in the proportion of extended-spectrum beta-lactamase (ESBL)-producing KP. However, the clinical and computed tomography (CT) features of liver abscesses caused by ESBL-producing KP have not been separately described. We aimed to compare the clinical and CT features present in patients with ESBL-producing and non-ESBL-producing KP as well as to determine the risk factors for ESBL-producing KP liver abscesses (KPLAs).
methodsWe performed a retrospective analysis of data obtained from the medical records of patients with a first episode of KPLA admitted to Shengjing Hospital of China Medical University between May 2015 and May 2019. We compared the clinical and CT features between patients with ESBL-producing and non-ESBL-producing KPLA.
resultsWe enrolled 100 patients with KPLA (14 and 86 in the ESBL-producing and non-ESBL-producing groups, respectively). There was no significant between-group difference in the proportion of patients with comorbid diabetes (71.43% vs. 66.2%, p = 0.086). The ESBL-producing KPLA group had a greater proportion of patients with a history of biliary disease (78.57% vs. 26.74%, p < 0.001) and gastrointestinal malignancy (50% vs. 6.98%, p < 0.001). Multivariate regression analysis showed that a history of biliary disease was an independent risk factor for ESBL-producing KPLA. Compared with the non-ESBL-producing KPLA group, the ESBL-producing KPLA group had a significantly higher intensive care unit (ICU) admission rate (28.57% vs. 2.33%, p < 0.001). All ESBL-producing KP isolates were susceptible to carbapenems and amikacin. Only the presence of multiloculation on CT was found to be significantly different between the groups (50% vs. 82.56%, p = 0.012).
conclusionsThe presence of biliary disease was an independent risk factor for ESBL-producing KPLA. Patients with ESBL-producing KPLA had a higher ICU admission rate, with only half of patients having evidence of multiloculation on CT.
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