Evidence map›Paper›PMID 32539586›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2020

Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study.

Chenghao Qiu, Chong Cui, Charlotte Hautefort, Antje Haehner, Jun Zhao, Qi Yao, Hui Zeng, Eric J Nisenbaum, Li Liu, Yu Zhao and 19 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 15 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Taste disorders in cancer patients and current therapeutic approaches: a narrative review of an understudied topic in supportive care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Chenghao QiuCenter of Stomatology, Shanghai Public Health Clinical Center, Shanghai, China.
Chong CuiENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Charlotte HautefortDepartment of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France.
Antje HaehnerSmell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Jun ZhaoCenter of Pediatrics, Shanghai Public Health Clinical Center, Shanghai, China.
Qi YaoDepartment of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hui ZengDepartment of Cardiovascularology, The Third People's Hospital of Shenzhen, Shenzhen, China.
Eric J NisenbaumDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Li LiuDepartment of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, China.
Yu ZhaoENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Di ZhangDepartment of Otolaryngology, The Third People's Hospital of Shenzhen, Shenzhen, China.
Corinna G LevineDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ivette CejasDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Qi DaiENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, China.
Philippe HermanDepartment of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France.
Clement JourdaineDepartment of Head and Neck Surgery, Hopital Lariboisiere, University of Paris, Paris, France.
Katja de WithDivision of Infectious Diseases, University Hospital Carl Gustav Carus at the TU Dresden, Dresden, Germany.
Julia DrafSmell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Bing ChenENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Dushyantha T JayaweeraDepartment of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA.
James C DennenyAmerican Academy of Otolaryngology-Head and Neck Surgery, Alexandria, Virginia, USA.
Roy CasianoDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Hongmeng YuENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Adrien A EshraghiDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Thomas HummelSmell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.
Xuezhong LiuDepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Yilai ShuENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Hongzhou LuDepartment of Infectious Diseases, Shanghai Public Health Clinical Center, Shanghai, China.

Funding

Institutional Career Development CoreKL2TR002737 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA, SCOTT, GWENDOLYN BARBARA · 2018 to 2022
$3.6M
NCATS NIH HHS KL2 TR002737
6 · The paper itself

Abstract

objectiveTo evaluate the prevalence and characteristics of olfactory or gustatory dysfunction in coronavirus disease 2019 (COVID-19) patients. STUDY

designMulticenter case series.

settingFive tertiary care hospitals (3 in China, 1 in France, 1 in Germany). SUBJECTS AND

methodsIn total, 394 polymerase chain reaction (PCR)-confirmed COVID-19-positive patients were screened, and those with olfactory or gustatory dysfunction were included. Data including demographics, COVID-19 severity, patient outcome, and the incidence and degree of olfactory and/or gustatory dysfunction were collected and analyzed. The Questionnaire of Olfactory Disorders (QOD) and visual analog scale (VAS) were used to quantify olfactory and gustatory dysfunction, respectively. All subjects at 1 hospital (Shanghai) without subjective olfactory complaints underwent objective testing.

resultsOf 394 screened subjects, 161 (41%) reported olfactory and/or gustatory dysfunction and were included. Incidence of olfactory and/or gustatory disorders in Chinese (n = 239), German (n = 39), and French (n = 116) cohorts was 32%, 69%, and 49%, respectively. The median age of included subjects was 39 years, 92 of 161 (57%) were male, and 10 of 161 (6%) were children. Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. Of subjects with objective olfactory testing, 10 of 90 demonstrated abnormal chemosensory function despite reporting normal subjective olfaction. Forty-three percent (44/102) of subjects with follow-up showed symptomatic improvement in olfaction or gustation.

conclusionsOlfactory and/or gustatory disorders may represent early or isolated symptoms of severe acute respiratory syndrome coronavirus 2 infection. They may serve as a useful additional screening criterion, particularly for the identification of patients in the early stages of infection.

Indexed as

BetacoronavirusEarly DiagnosisAdolescentAdultChildChinaCoronavirus InfectionsCOVID-19FemaleFranceGermanyHumansMaleOlfaction DisordersPandemicsPneumonia, ViralanosmiaCOVID-19COVID-19 screeningdysgeusiagustatory dysfunctionolfactory dysfunctionSARS-CoV-2

Identifiers

PMID32539586
PMCPMC7298561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.