Evidence map›Paper›PMID 32539447›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Procalcitonin as a Marker of Comorbid Atrial Fibrillation in Chronic Kidney Disease and History of Sepsis.

Jack Bontekoe, Vinod Bansal, Justin Lee, Mushabbar Syed, Debra Hoppensteadt, Paula Maia, Amanda Walborn, Jeffrey Liles, Smit Vasaiwala, Jawed Fareed

Open access · goldAbstract read
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. The association of coagulation and atrial fibrillation: a systematic review and meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB.Journal of clinical tuberculosis and other mycobacterial diseases · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jack BontekoeDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.ORCID https://orcid.org/0000-0003-1379-2943
Vinod BansalDepartment of Nephrology, Loyola University Medical Center, Maywood, IL, USA.
Justin LeeDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.ORCID https://orcid.org/0000-0002-2231-4831
Mushabbar SyedDepartment of Cardiology, Loyola University Medical Center, Maywood, IL, USA.
Debra HoppensteadtDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.ORCID https://orcid.org/0000-0001-9342-4213
Paula MaiaDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.
Amanda WalbornDepartment of Pharmacology, Loyola University Medical Center, Maywood, IL, USA.ORCID https://orcid.org/0000-0001-8235-3624
Jeffrey LilesDepartment of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, IL, USA.
Smit VasaiwalaDepartment of Cardiology, Loyola University Medical Center, Maywood, IL, USA.
Jawed FareedDepartment of Pathology, Loyola University Medical Center, Maywood, IL, USA.ORCID https://orcid.org/0000-0003-3465-2499
Loyola University Medical Center · US

Funding

Basic and Clinical Research Training for Medical StudentsT35HL120835 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZELEZNIK-LE, NANCY J · 2015 to 2024
$628k
NHLBI NIH HHS T35 HL120835
6 · The paper itself

Abstract

Cardiovascular disease and infection are the leading causes of mortality in patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD). Inflammation is a large component in the pathogenesis of both atrial fibrillation (AF) and sepsis and may link these conditions in CKD5-HD. Procalcitonin (PCT) is an inflammatory biomarker elevated in systemic infection and CKD5-HD, yet its value with regard to comorbid AF has not been thoroughly investigated. The aim of this study sought to evaluate circulating inflammatory markers, including PCT, Angiopoietin-1, Angiopoetin-2, CD40-L, C-reactive protein, d-dimer, and von Willebrand factor in relation to these conditions. Plasma levels of inflammatory markers were measured by enzyme linked immunosorbent assay method in CKD5-HD (n = 97) patients and controls (n = 50). Procalcitonin levels were significantly elevated (

Indexed as

AdultAgedAged, 80 and overAtrial FibrillationFemaleHumansMaleMiddle AgedProcalcitoninRenal Insufficiency, ChronicSepsisYoung AdultProcalcitoninatrial fibrillationbiomarkerschronic kidney diseasehemodialysisprocalcitoninsepsis

Identifiers

PMID32539447
PMCPMC7427007
OpenAlexW3035704859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.